Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score

• Main Authors: Huynh-Le, Minh-Phuong, Karunamuni, Roshan, Fan, Chun Chieh, Asona, Lui, Thompson, Wesley K., Martinez, Maria Elena, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth R., Lophatananon, Artitaya, Schleutker, Johanna, Pashayan, Nora, Batra, Jyotsna, Groenberg, Henrik, Neal, David E., Nordestgaard, Borge G., Tangen, Catherine M., MacInnis, Robert J., Wolk, Alicja, Albanes, Demetrius, Haiman, Christopher A., Travis, Ruth C., Blot, William J., Stanford, Janet L., Mucci, Lorelei A., West, Catharine M. L., Nielsen, Sune F., Kibel, Adam S., Cussenot, Olivier, Berndt, Sonja, Koutros, Stella, Sorensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Menegaux, Florence, Park, Jong Y., Ingles, Sue A., Maier, Christiane, Hamilton, Robert J., Rosenstein, Barry S., Lu, Yong-Jie, Watya, Stephen, Vega, Ana, Kogevinas, Manolis, Wiklund, Fredrik, Penney, Kathryn L., Huff, Chad D., Teixeira, Manuel R., Multigner, Luc, Leach, Robin J., Brenner, Hermann, John, Esther M., Kaneva, Radka, Logothetis, Christopher J., Neuhausen, Susan L., De Ruyck, Kim, Ost, Piet, Razack, Azad Hassan Abdul, Newcomb, Lisa F., Fowke, Jay H., Gamulin, Marija, Abraham, Aswin, Claessens, Frank, Castelao, Jose Esteban, Townsend, Paul A., Crawford, Dana C., Petrovics, Gyorgy, van Schaik, Ron H. N., Parent, Marie-Elise, Hu, Jennifer J., Zheng, Wei, Mills, Ian G., Andreassen, Ole A., Dale, Anders M., Seibert, Tyler M.
• Format: Article
• Published: Springernature 2022
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://eprints.um.edu.my/46285/; https://doi.org/10.1038/s41391-022-00497-7
• Institution: Universiti Malaya

Background Prostate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increased accuracy. We evaluated whether including additional SNPs in a prostate cancer...