Manzamine A reduces androgen receptor transcription and synthesis by blocking E2F8-DNA interactions and effectively inhibits prostate tumor growth in mice

• Main Authors: Karan, Dev, Dubey, Seema, Gunewardena, Sumedha, Iczkowski, Kenneth A., Singh, Manohar, Liu, Pengyuan, Poletti, Angelo, Choo, Yeun-Mun, Chen, Hui-Zi, Hamann, Mark T.
• Format: Article
• Published: Wiley 2024
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://eprints.um.edu.my/46994/; https://doi.org/10.1002/1878-0261.13637
• Institution: Universiti Malaya

The androgen receptor (AR) is the main driver in the development of castration-resistant prostate cancer, where the emergence of AR splice variants leads to treatment-resistant disease. Through detailed molecular studies of the marine alkaloid manzamine A (MA), we identified transcription factor E2F...