Rescue of paclitaxel sensitivity by repression of Prohibitin1 in drug-resistant cancer cells

• Main Authors: Patel, Nish, Chatterjee, Sabarni K., Vrbanac, Vladimir, Chung, Ivy, Mu, Chunyao Jenny, Olsen, Rachelle R., Waghorne, Carol, Zetter, Bruce R.
• Format: Article
• Published: National Academy of Sciences 2010
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/5085/; https://doi.org/10.1073/pnas.0910649107
• Institution: Universiti Malaya

Paclitaxel has emerged as a front line treatment for aggressive malignancies of the breast, lung, and ovary. Successful therapy of cancer is frequently undermined by the development of paclitaxel resistance. There is a growing need to find other therapeutic targets to facilitate treatment of drug-re...