Prevalence of bilateral 'mirror-image' lesions in patients with oral potentially malignant epithelial lesions
Early detection of oral potentially malignant epithelial lesions (PMELs) is aimed at improving survival rates as carcinogenesis is a multistep process and prevention is possible if these lesions are detected at an early and reversible stage of the disease. A prospective clinical study aimed at deter...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer Verlag (Germany)
2012
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/6076/1/Prevalence_of_bilateral_%27mirror-image%27_lesions_in_patients_with_oral_potentially_malignant_epithelial_lesions.pdf http://eprints.um.edu.my/6076/ |
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| Institution: | Universiti Malaya |
| Language: | English |
| Summary: | Early detection of oral potentially malignant epithelial lesions (PMELs) is aimed at improving survival rates as carcinogenesis is a multistep process and prevention is possible if these lesions are detected at an early and reversible stage of the disease. A prospective clinical study aimed at determining the prevalence of bilateral 'mirror-image' oral PMELs was carried out. Sample consisted of 32 (53.3) Indians, 23 (38.3) Chinese, 4 (6.7) Malays and one (1.7) Nepalese. All had histopathological confirmation of their primary existing PMEL as inclusion criteria. A total of 70 primary lesions were detected. The most common PMEL found was oral lichen planus. Of these, 28 (46.7) patients exhibited bilateral 'mirror-image' lesions (n = 42) either synchronously (n = 32/42) or metachronously (n = 10/42). The remaining 32 (53.3) patients had normal-looking contralateral mucosa. Present findings suggest that patients presenting with oral PMELs are at greater risk of developing a second lesion, most probably in the contralateral 'mirror-image' site. |
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