Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration
Spices are rich sources of antioxidants due to the presence of phenols and flavonoids. In this study, the DNA protecting activity and inhibition of nicotine-induced cancer cell migration of 9 spices were analysed. Murine fibroblasts (3T3-L1) and human breast cancer (MCF-7) cells were pre-treated wit...
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my.um.eprints.71572014-12-26T03:58:53Z http://eprints.um.edu.my/7157/ Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration Jayakumar, R. Kanthimathi, M.S. R Medicine Spices are rich sources of antioxidants due to the presence of phenols and flavonoids. In this study, the DNA protecting activity and inhibition of nicotine-induced cancer cell migration of 9 spices were analysed. Murine fibroblasts (3T3-L1) and human breast cancer (MCF-7) cells were pre-treated with spice extracts and then exposed to H 2O 2 and nicotine. The comet assay was used to analyse the DNA damage. Among the 9 spices, ginger, at 50 μg/ml protected against 68 of DNA damage in 3T3-L1 cells. Caraway, cumin and fennel showed statistically significant (p < 0.05) DNA protecting activity. Treatment of MCF-7 cells with nicotine induced cell migration, whereas pre-treatment with spices reduced this migration. Pepper, long pepper and ginger exhibited a high rate of inhibition of cell migration. The results of this study prove that spices protect DNA and inhibit cancer cell migration. © 2012 Elsevier Ltd. All rights reserved. 2012 Article PeerReviewed Jayakumar, R. and Kanthimathi, M.S. (2012) Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration. Food Chemistry, 134 (3). pp. 1580-1584. ISSN 0308-8146 10.1016/j.foodchem.2012.03.101 |
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R Medicine Jayakumar, R. Kanthimathi, M.S. Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration |
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Spices are rich sources of antioxidants due to the presence of phenols and flavonoids. In this study, the DNA protecting activity and inhibition of nicotine-induced cancer cell migration of 9 spices were analysed. Murine fibroblasts (3T3-L1) and human breast cancer (MCF-7) cells were pre-treated with spice extracts and then exposed to H 2O 2 and nicotine. The comet assay was used to analyse the DNA damage. Among the 9 spices, ginger, at 50 μg/ml protected against 68 of DNA damage in 3T3-L1 cells. Caraway, cumin and fennel showed statistically significant (p < 0.05) DNA protecting activity. Treatment of MCF-7 cells with nicotine induced cell migration, whereas pre-treatment with spices reduced this migration. Pepper, long pepper and ginger exhibited a high rate of inhibition of cell migration. The results of this study prove that spices protect DNA and inhibit cancer cell migration. © 2012 Elsevier Ltd. All rights reserved. |
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Article |
author |
Jayakumar, R. Kanthimathi, M.S. |
author_facet |
Jayakumar, R. Kanthimathi, M.S. |
author_sort |
Jayakumar, R. |
title |
Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration |
title_short |
Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration |
title_full |
Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration |
title_fullStr |
Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration |
title_full_unstemmed |
Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration |
title_sort |
dietary spices protect against hydrogen peroxide-induced dna damage and inhibit nicotine-induced cancer cell migration |
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2012 |
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http://eprints.um.edu.my/7157/ |
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