Effect of ribavirin on zidovudine efficacy and toxicity in vitro: A concentration-dependent interaction

• Main Authors: Sim, S.M., Hoggard, P.G., Sales, S.D., Phiboonbanakit, D., Hart, C.A., Back, D.J.
• Format: Article
• Published: 1998
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/7692/; http://www.ncbi.nlm.nih.gov/pubmed/9870320
• Institution: Universiti Malaya

Zidovudine (ZDV) is converted to its active triphosphate (ZDVTP) by intracellular kinases, The intermediate ZDV monophosphate (ZDVMP) is believed to play a major role in ZDV toxicity. Manipulation of ZDV phosphorylation is a possible therapeutic strategy for altering the risk-benefit ratio, Here we...