BODIPY dyes in photodynamic therapy
BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet stat...
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my.um.eprints.81502013-07-22T00:40:52Z http://eprints.um.edu.my/8150/ BODIPY dyes in photodynamic therapy Kamkaew, A. Lim, S.H. Lee, H.B. Kiew, L.V. Chung, L.Y. Burgess, K. R Medicine BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet states. Singlet oxygen is formed when these triplet states interact with O-3(2). In tissues, this causes cell damage in regions that are illuminated, and this is the basis of photodynamic therapy (PDT). The PDT agents that are currently approved for clinical use do not feature BODIPYs, but there are many reasons to believe that this situation will change. This review summarizes the attributes of BODIPY dyes for PDT, and in some related areas. 2013 Article PeerReviewed application/pdf en http://eprints.um.edu.my/8150/1/Kamkaew-2013-BODIPY_dyes_in_photo.pdf Kamkaew, A. and Lim, S.H. and Lee, H.B. and Kiew, L.V. and Chung, L.Y. and Burgess, K. (2013) BODIPY dyes in photodynamic therapy. Chemical Society Reviews, 42 (1). pp. 77-88. ISSN 0306-0012 http://www.ncbi.nlm.nih.gov/pubmed/23014776 10.1039/c2cs35216h |
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R Medicine Kamkaew, A. Lim, S.H. Lee, H.B. Kiew, L.V. Chung, L.Y. Burgess, K. BODIPY dyes in photodynamic therapy |
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BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet states. Singlet oxygen is formed when these triplet states interact with O-3(2). In tissues, this causes cell damage in regions that are illuminated, and this is the basis of photodynamic therapy (PDT). The PDT agents that are currently approved for clinical use do not feature BODIPYs, but there are many reasons to believe that this situation will change. This review summarizes the attributes of BODIPY dyes for PDT, and in some related areas. |
format |
Article |
author |
Kamkaew, A. Lim, S.H. Lee, H.B. Kiew, L.V. Chung, L.Y. Burgess, K. |
author_facet |
Kamkaew, A. Lim, S.H. Lee, H.B. Kiew, L.V. Chung, L.Y. Burgess, K. |
author_sort |
Kamkaew, A. |
title |
BODIPY dyes in photodynamic therapy |
title_short |
BODIPY dyes in photodynamic therapy |
title_full |
BODIPY dyes in photodynamic therapy |
title_fullStr |
BODIPY dyes in photodynamic therapy |
title_full_unstemmed |
BODIPY dyes in photodynamic therapy |
title_sort |
bodipy dyes in photodynamic therapy |
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2013 |
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http://eprints.um.edu.my/8150/1/Kamkaew-2013-BODIPY_dyes_in_photo.pdf http://eprints.um.edu.my/8150/ http://www.ncbi.nlm.nih.gov/pubmed/23014776 |
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