Bio-functionalization of lanthanide phosphate nanoparticles / Abbas Abdulameer Salman

A series of new surface modification reagents were synthesized and applied on LaPO4:Ce,Tb nanoparticles surfaces by postsynthetic and in-situ nanoparticle modification. The compounds comprise of an oligo-ethlyne glycol backbone that is connecting an organic phosphonate function (ester, acid or acid...

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Main Author: Salman, Abbas Abdulameer
Format: Thesis
Published: 2014
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Online Access:http://studentsrepo.um.edu.my/4900/1/Final_Thesis.docx
http://studentsrepo.um.edu.my/4900/
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spelling my.um.stud.49002015-03-05T08:03:13Z Bio-functionalization of lanthanide phosphate nanoparticles / Abbas Abdulameer Salman Salman, Abbas Abdulameer Q Science (General) QD Chemistry A series of new surface modification reagents were synthesized and applied on LaPO4:Ce,Tb nanoparticles surfaces by postsynthetic and in-situ nanoparticle modification. The compounds comprise of an oligo-ethlyne glycol backbone that is connecting an organic phosphonate function (ester, acid or acid salt) and a reactive functional group (azide or alkyne), suitable for coupling with complimentary functionalized carbohydrates by cycloaddition in click chemistry fashion. The objective of this chemical functionalization of a nanoparticle is to attach a biological receptor that enables subsequent direction of the particle in the human body for related life science application, e.g. as radio-contrast reagent for the specific recognition of cancer cells. The bio-labeling process involves two stages; in the initial stage the phosphonate binds covalently to the surface, thus chemically attaching the reactive functional group to the particle. Subsequent coupling with receptor under mild click-chemistry conditions enables the binding of the latter to the particle. Monitoring of chemical changes at the particle surface was based on IR-spectroscopy. The reaction progress was monitored by tracking azide and carbonyl vibrations. The particle loading with the organic ligand was confirmed by TGA. Furthermore, the size, shape and morphology of the LaPO4:Ce,Tb nanocrystals were examined by XRD, SAXS and transmission electron microscopy. The experimental results confirm a previously reported narrow monodisperse distribution of ellipsoidal nanoparticle with 5-7 nm diameter. They also indicate no effect of neither surface modification nor subsequent click coupling on the particle morphology. 2014 Thesis NonPeerReviewed application/msword http://studentsrepo.um.edu.my/4900/1/Final_Thesis.docx Salman, Abbas Abdulameer (2014) Bio-functionalization of lanthanide phosphate nanoparticles / Abbas Abdulameer Salman. PhD thesis, University of Malaya. http://studentsrepo.um.edu.my/4900/
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Student Repository
url_provider http://studentsrepo.um.edu.my/
topic Q Science (General)
QD Chemistry
spellingShingle Q Science (General)
QD Chemistry
Salman, Abbas Abdulameer
Bio-functionalization of lanthanide phosphate nanoparticles / Abbas Abdulameer Salman
description A series of new surface modification reagents were synthesized and applied on LaPO4:Ce,Tb nanoparticles surfaces by postsynthetic and in-situ nanoparticle modification. The compounds comprise of an oligo-ethlyne glycol backbone that is connecting an organic phosphonate function (ester, acid or acid salt) and a reactive functional group (azide or alkyne), suitable for coupling with complimentary functionalized carbohydrates by cycloaddition in click chemistry fashion. The objective of this chemical functionalization of a nanoparticle is to attach a biological receptor that enables subsequent direction of the particle in the human body for related life science application, e.g. as radio-contrast reagent for the specific recognition of cancer cells. The bio-labeling process involves two stages; in the initial stage the phosphonate binds covalently to the surface, thus chemically attaching the reactive functional group to the particle. Subsequent coupling with receptor under mild click-chemistry conditions enables the binding of the latter to the particle. Monitoring of chemical changes at the particle surface was based on IR-spectroscopy. The reaction progress was monitored by tracking azide and carbonyl vibrations. The particle loading with the organic ligand was confirmed by TGA. Furthermore, the size, shape and morphology of the LaPO4:Ce,Tb nanocrystals were examined by XRD, SAXS and transmission electron microscopy. The experimental results confirm a previously reported narrow monodisperse distribution of ellipsoidal nanoparticle with 5-7 nm diameter. They also indicate no effect of neither surface modification nor subsequent click coupling on the particle morphology.
format Thesis
author Salman, Abbas Abdulameer
author_facet Salman, Abbas Abdulameer
author_sort Salman, Abbas Abdulameer
title Bio-functionalization of lanthanide phosphate nanoparticles / Abbas Abdulameer Salman
title_short Bio-functionalization of lanthanide phosphate nanoparticles / Abbas Abdulameer Salman
title_full Bio-functionalization of lanthanide phosphate nanoparticles / Abbas Abdulameer Salman
title_fullStr Bio-functionalization of lanthanide phosphate nanoparticles / Abbas Abdulameer Salman
title_full_unstemmed Bio-functionalization of lanthanide phosphate nanoparticles / Abbas Abdulameer Salman
title_sort bio-functionalization of lanthanide phosphate nanoparticles / abbas abdulameer salman
publishDate 2014
url http://studentsrepo.um.edu.my/4900/1/Final_Thesis.docx
http://studentsrepo.um.edu.my/4900/
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