Natural cholinesterase inhibitors from Myristica cinnamomea king / Siti Mariam Abdul Wahab
A new acylphenol, malabaricone E (72) together with the known malabaricones A-C (1- 3), maingayones A and B (4 and 5) and maingayic acid B (69) were isolated from the ethyl acetate extract of the fruits of Myristica cinnamomea King. Their structures were determined by 1D and 2D NMR techniques and...
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my.um.stud.96652019-08-04T22:55:46Z Natural cholinesterase inhibitors from Myristica cinnamomea king / Siti Mariam Abdul Wahab Siti Mariam , Abdul Wahab Q Science (General) A new acylphenol, malabaricone E (72) together with the known malabaricones A-C (1- 3), maingayones A and B (4 and 5) and maingayic acid B (69) were isolated from the ethyl acetate extract of the fruits of Myristica cinnamomea King. Their structures were determined by 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Compounds 2 (1.84 ± 0.19 and 1.76 ± 0.21 μM, respectively) and 3 (1.94 ± 0.27 and 2.80 ± 0.49 μM, respectively) were identified as dual inhibitors, with almost equal acetylcholinesterase enzyme (AChE) and butyrylcholinesterase enzyme (BChE) inhibiting potentials. The Lineweaver-Burk plots of compounds 2 and 3 indicated that they were mixed-mode inhibitors. Based on the molecular docking studies, compounds 2 and 3 interacted with the peripheral anionic site (PAS), the catalytic triad and the oxyanion hole of the AChE. As for the BChE, while compound 2 interacted with the PAS, the catalytic triad and the oxyanion hole, compound 3 only interacted with the catalytic triad and the oxyanion hole. 2016-11 Thesis NonPeerReviewed application/pdf http://studentsrepo.um.edu.my/9665/1/Siti_Mariam_Abdul_Wahab.pdf application/pdf http://studentsrepo.um.edu.my/9665/8/mariam.pdf Siti Mariam , Abdul Wahab (2016) Natural cholinesterase inhibitors from Myristica cinnamomea king / Siti Mariam Abdul Wahab. Masters thesis, University of Malaya. http://studentsrepo.um.edu.my/9665/ |
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Q Science (General) Siti Mariam , Abdul Wahab Natural cholinesterase inhibitors from Myristica cinnamomea king / Siti Mariam Abdul Wahab |
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A new acylphenol, malabaricone E (72) together with the known malabaricones A-C (1-
3), maingayones A and B (4 and 5) and maingayic acid B (69) were isolated from the
ethyl acetate extract of the fruits of Myristica cinnamomea King. Their structures were
determined by 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Compounds 2
(1.84 ± 0.19 and 1.76 ± 0.21 μM, respectively) and 3 (1.94 ± 0.27 and 2.80 ± 0.49 μM,
respectively) were identified as dual inhibitors, with almost equal acetylcholinesterase
enzyme (AChE) and butyrylcholinesterase enzyme (BChE) inhibiting potentials. The
Lineweaver-Burk plots of compounds 2 and 3 indicated that they were mixed-mode
inhibitors. Based on the molecular docking studies, compounds 2 and 3 interacted with
the peripheral anionic site (PAS), the catalytic triad and the oxyanion hole of the AChE.
As for the BChE, while compound 2 interacted with the PAS, the catalytic triad and the
oxyanion hole, compound 3 only interacted with the catalytic triad and the oxyanion
hole. |
format |
Thesis |
author |
Siti Mariam , Abdul Wahab |
author_facet |
Siti Mariam , Abdul Wahab |
author_sort |
Siti Mariam , Abdul Wahab |
title |
Natural cholinesterase inhibitors from Myristica cinnamomea king / Siti Mariam Abdul Wahab |
title_short |
Natural cholinesterase inhibitors from Myristica cinnamomea king / Siti Mariam Abdul Wahab |
title_full |
Natural cholinesterase inhibitors from Myristica cinnamomea king / Siti Mariam Abdul Wahab |
title_fullStr |
Natural cholinesterase inhibitors from Myristica cinnamomea king / Siti Mariam Abdul Wahab |
title_full_unstemmed |
Natural cholinesterase inhibitors from Myristica cinnamomea king / Siti Mariam Abdul Wahab |
title_sort |
natural cholinesterase inhibitors from myristica cinnamomea king / siti mariam abdul wahab |
publishDate |
2016 |
url |
http://studentsrepo.um.edu.my/9665/1/Siti_Mariam_Abdul_Wahab.pdf http://studentsrepo.um.edu.my/9665/8/mariam.pdf http://studentsrepo.um.edu.my/9665/ |
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