Synthesis of N-(3-picolyl)-based 1,3,2λ5-benzoxazaphosphinamides as potential 11β-HSD1 enzyme inhibitors

• Main Authors: Balam, S.K., Krishnammagari, S.K., Soora Harinath, J, Sthanikam, S.P., Chereddy,S.S., Pasupuleti, V.R., Yellapu, N.K., Peddiahgari, V.G.R., Cirandur, S.R.
• Format: Non-Indexed Article
• Published: Springer Science Media New York 2015
• Online Access: http://discol.umk.edu.my/id/eprint/8271/; http://www.academia.edu/19358011/Synthesis_of_N-_3-picolyl_-based_1_3_2%CE%BB5-benzoxazaphosphinamides_as_potential_11%CE%B2-HSD1_enzyme_inhibitors
• Institution: Universiti Malaysia Kelantan

Inhibition of 11β-HSD1 enzymatic action is perceived as a potential target for the treatment of metabolic syndromes like cardiovascular diseases, obesity, and diabetes. In an attempt to formulate potential organophosphorus compounds against 11β-HSD1 enzyme inhibition, we report novel 6-bromo-3-(6-me...