Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis

• Main Authors: Fatanah, M. Suhaimi, Chase, J. Geoffrey, Pretty, G. Christopher, Shaw, M. Geoffrey, Normy Norfiza, A. Razak, Ummu Kulthum, Jamaludin
• Format: Article
• Language: English; English
• Published: Elsevier Ltd 2015
• Subjects: TJ Mechanical engineering and machinery
• Online Access: http://umpir.ump.edu.my/id/eprint/11198/1/Insulin%20Sensitivity%20as%20a%20Model-Based%20Marker%20for%20Sepsis%20Diagnosis.pdf; http://umpir.ump.edu.my/id/eprint/11198/7/Insulin%20Sensitivity%20as%20a%20Model-Based%20Marker%20for%20Sepsis%20Diagnosis.pdf; http://umpir.ump.edu.my/id/eprint/11198/; http://dx.doi.org/10.1016/j.ifacol.2015.10.168
• Institution: Universiti Malaysia Pahang

Sepsis is highly associated with microcirculatory dysfunction, which normally results in organ failure and increased risk of death. Importantly, early goal-directed therapy observed lower mortality rates in septic shock patients compared to those assigned to standard therapy. Currently, it is almost impossible to diagnose a patient at the onset of sepsis due to the lack of real-time metrics with high sensitivity and specificity. Patient condition is mostly determined by clinician experience and observation of patient reaction to treatment. In this study, a model-based insulin sensitivity profile is used to identify the relation between individual metabolic conditions to their sepsis status. The hour-to-hour variation of insulin sensitivity is highly independent of the treatment received by the patient and may represent a metabolic status for real-time diagnosis of sepsis. The hour-to-hour variation of insulin sensitivity profile is analyzed with sepsis score calculated according to the definition provided by ACCP/SCCM. P-values of various sepsis score group are computed using Mann-Whitney test. Cumulative distribution function of insulin sensitivity shows separation between different sepsis score and more distinguishable at a higher sepsis score compared to the lower sepsis score.