Synthesis of an Anthraquinone Derivative (DHAQC) and its Effect on Induction of G2/M Arrest and Apoptosis in Breast Cancer MCF-7 Cell Line

• Main Authors: Swee, Keong Yeap, Akhtar, Muhammad Nadeem, Kian, Lam Lim, Nadiah, Abu, Wan, Yong Ho, Seema, Zareen, Kiarash, Roohani, Huynh, Ky, Sheau, Wei Tan, Nordin, Lajis, Noorjahan Banu, Alitheen
• Format: Article
• Language: English
• Published: Dove Press Ltd 2015
• Subjects: Q Science (General)
• Online Access: http://umpir.ump.edu.my/id/eprint/11270/1/Synthesis%20of%20an%20anthraquinone%20derivative%20%28DHAQC%29%20and%20its%20effect%20on%20induction%20of%20G2-M%20arrest%20and%20apoptosis%20in%20breast%20cancer%20MCF-7%20cell%20line.pdf; http://umpir.ump.edu.my/id/eprint/11270/; http://dx.doi.org/10.2147/DDDT.S65468
• Institution: Universiti Malaysia Pahang

Anthraquinones are an important class of naturally occurring biologically active compounds. In this study, anthraquinone derivative 1,3-dihydroxy-9,10-anthraquinone-2- carboxylic acid (DHAQC) (2) was synthesized with 32% yield through the Friedel–Crafts condensation reaction. The mechanisms of cytot...