Cocrystal screening of ibuprofen with oxalic acid and citric acid via grinding method

• Main Authors: M. F., Othman, N., Anuar, Sunarti, Abd Rahman, N. A ., Ahmad Taifuddin
• Format: Conference or Workshop Item
• Language: English; English
• Published: IOP Publishing 2017
• Subjects: TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/23022/1/Cocrystal%20screening%20of%20ibuprofen%20with%20oxalic%20acid%20and%20citric%20acid%20via%20grinding%20method.pdf; http://umpir.ump.edu.my/id/eprint/23022/7/Cocrystal%20Screening%20of%20Ibuprofen%20with%20Oxalic%20Acid%20and%20Citric%20Acid%20via%20Grinding%20Method.pdf; http://umpir.ump.edu.my/id/eprint/23022/; https://doi.org/10.1088/1757-899X/358/1/012065
• Institution: Universiti Malaysia Pahang

Ibuprofen is a Class II Biological Safety Class (BSC) drugs used for relief of arthritis, as an analgesic and possesses the effect of antiplatelet. The major problem involves in ibuprofen is it has a low solubility and high permeability thus causes an unsatisfactory therapeutic effect to humans. Thus, in this work, alteration of ibuprofen's physicochemical properties is conducted by means of cocrystallization technique. Co-crystallizations of ibuprofen were prepared with selected coformers using dry grinding and liquid assisted grinding (LAG) techniques in different molar ratios while ethanol and propanol were used as a solvent. The new crystalline forms were identified and characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and fourier transform infrared spectroscopy (FTIR). Analysis for Ibuprofen-Citric acid (IBP-CA) system, co-crystal was successfully formed in 1:2, 1:3, 2:1 and 3:1 molar ratios for neat grinding method although the co-crystal produced is unstable. Meanwhile, for Ibuprofen-Oxalic acid (IBP-OA) system, the co-crystal formation was identified only in 1:1, 1:2 and 1:3 molar ratios for the neat grinding method. LAG method shows that co-crystal formation was unsuccessful in both solvents for IBP-CA, while IBP-OA co-crystal was formed in the molar ratio 1:1, 2:1 and 3:1 in ethanol, and 2:1 and 3:1 in propanol.