Insights on the synthesis of asymmetric curcumin derivatives and their biological activities

• Main Authors: Poh, Yen Khor, Mohd F. F., Mohd Aluwi, Kamal, Rullah, Kok, Wai Lam
• Format: Article
• Language: English
• Published: Elsevier 2019
• Subjects: QD Chemistry; RM Therapeutics. Pharmacology; RS Pharmacy and materia medica; TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/26063/1/Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin%20derivatives%20.pdf; http://umpir.ump.edu.my/id/eprint/26063/; https://doi.org/10.1016/j.ejmech.2019.111704; https://doi.org/10.1016/j.ejmech.2019.111704
• Institution: Universiti Malaysia Pahang

Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods...