Evaluation of antihypercholesterolemic effect using Memecylon edule Roxb. ethanolic extract in cholesterol-induced Swiss albino mice

Purpose/Aim: In the present study, we investigate the antihypercholesterolemic effect of the ethanolic extract of Memecylon edule in in vivo. Methods: Cholesterol (1%) -induced experimental groups were treated with 100 mg/kg and 200 mg/kg M. edule ethanolic extract. The study period of antihyperchol...

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Main Authors: Kuppusamy, Palaniselvam, Paul Raj, R.S. David, Ilavenil, Soundharrajan, Kaleeswaran, Balasubramanian, Govindan, Natanamurugaraj, Maniam, Gaanty Pragas, Ravikumar, Sivanesan
Format: Article
Language:English
Published: Elsevier 2015
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Online Access:http://umpir.ump.edu.my/id/eprint/29804/1/Evaluation%20of%20antihypercholesterolemic%20effect%20using%20Memecylon%20edule%20Roxb.pdf
http://umpir.ump.edu.my/id/eprint/29804/
https://doi.org/10.1016/j.jacme.2015.09.001
https://doi.org/10.1016/j.jacme.2015.09.001
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Institution: Universiti Malaysia Pahang Al-Sultan Abdullah
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spelling my.ump.umpir.298042022-11-10T02:10:50Z http://umpir.ump.edu.my/id/eprint/29804/ Evaluation of antihypercholesterolemic effect using Memecylon edule Roxb. ethanolic extract in cholesterol-induced Swiss albino mice Kuppusamy, Palaniselvam Paul Raj, R.S. David Ilavenil, Soundharrajan Kaleeswaran, Balasubramanian Govindan, Natanamurugaraj Maniam, Gaanty Pragas Ravikumar, Sivanesan QP Physiology T Technology (General) TP Chemical technology Purpose/Aim: In the present study, we investigate the antihypercholesterolemic effect of the ethanolic extract of Memecylon edule in in vivo. Methods: Cholesterol (1%) -induced experimental groups were treated with 100 mg/kg and 200 mg/kg M. edule ethanolic extract. The study period of antihypercholesterolemia, the mice body weight, lipid profile, serum enzymes (such as superoxide dismutase, catalase, and glutathione peroxidase), liver marker enzyme, and histopathological study of liver tissues were examined. Results: The M. edule-treated groups have exhibited significant changes in total cholesterol, very-low-density lipoprotein, and low-density lipoprotein, and eventually increased the high-density-lipoprotein activity in serum. Also, it reduced the malondialdehyde level and increased the antioxidant-enzyme activities. The activity is mainly the presence of flavonoids, tannins, saponins, and glycosides in the ethanolic extract of M. edule. Conclusion; The M. edule extract contains a different class of secondary metabolites, which reduces the hypercholesterolemic condition in the experimental animal model. The results explored the M. edule extract as a potent drug for hypercholesterolemic condition. Elsevier 2015-12-01 Article PeerReviewed pdf en cc_by_nc_nd_4 http://umpir.ump.edu.my/id/eprint/29804/1/Evaluation%20of%20antihypercholesterolemic%20effect%20using%20Memecylon%20edule%20Roxb.pdf Kuppusamy, Palaniselvam and Paul Raj, R.S. David and Ilavenil, Soundharrajan and Kaleeswaran, Balasubramanian and Govindan, Natanamurugaraj and Maniam, Gaanty Pragas and Ravikumar, Sivanesan (2015) Evaluation of antihypercholesterolemic effect using Memecylon edule Roxb. ethanolic extract in cholesterol-induced Swiss albino mice. Journal of Acute Medicine, 5 (4). pp. 85-91. ISSN 2211-5587. (Published) https://doi.org/10.1016/j.jacme.2015.09.001 https://doi.org/10.1016/j.jacme.2015.09.001
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic QP Physiology
T Technology (General)
TP Chemical technology
spellingShingle QP Physiology
T Technology (General)
TP Chemical technology
Kuppusamy, Palaniselvam
Paul Raj, R.S. David
Ilavenil, Soundharrajan
Kaleeswaran, Balasubramanian
Govindan, Natanamurugaraj
Maniam, Gaanty Pragas
Ravikumar, Sivanesan
Evaluation of antihypercholesterolemic effect using Memecylon edule Roxb. ethanolic extract in cholesterol-induced Swiss albino mice
description Purpose/Aim: In the present study, we investigate the antihypercholesterolemic effect of the ethanolic extract of Memecylon edule in in vivo. Methods: Cholesterol (1%) -induced experimental groups were treated with 100 mg/kg and 200 mg/kg M. edule ethanolic extract. The study period of antihypercholesterolemia, the mice body weight, lipid profile, serum enzymes (such as superoxide dismutase, catalase, and glutathione peroxidase), liver marker enzyme, and histopathological study of liver tissues were examined. Results: The M. edule-treated groups have exhibited significant changes in total cholesterol, very-low-density lipoprotein, and low-density lipoprotein, and eventually increased the high-density-lipoprotein activity in serum. Also, it reduced the malondialdehyde level and increased the antioxidant-enzyme activities. The activity is mainly the presence of flavonoids, tannins, saponins, and glycosides in the ethanolic extract of M. edule. Conclusion; The M. edule extract contains a different class of secondary metabolites, which reduces the hypercholesterolemic condition in the experimental animal model. The results explored the M. edule extract as a potent drug for hypercholesterolemic condition.
format Article
author Kuppusamy, Palaniselvam
Paul Raj, R.S. David
Ilavenil, Soundharrajan
Kaleeswaran, Balasubramanian
Govindan, Natanamurugaraj
Maniam, Gaanty Pragas
Ravikumar, Sivanesan
author_facet Kuppusamy, Palaniselvam
Paul Raj, R.S. David
Ilavenil, Soundharrajan
Kaleeswaran, Balasubramanian
Govindan, Natanamurugaraj
Maniam, Gaanty Pragas
Ravikumar, Sivanesan
author_sort Kuppusamy, Palaniselvam
title Evaluation of antihypercholesterolemic effect using Memecylon edule Roxb. ethanolic extract in cholesterol-induced Swiss albino mice
title_short Evaluation of antihypercholesterolemic effect using Memecylon edule Roxb. ethanolic extract in cholesterol-induced Swiss albino mice
title_full Evaluation of antihypercholesterolemic effect using Memecylon edule Roxb. ethanolic extract in cholesterol-induced Swiss albino mice
title_fullStr Evaluation of antihypercholesterolemic effect using Memecylon edule Roxb. ethanolic extract in cholesterol-induced Swiss albino mice
title_full_unstemmed Evaluation of antihypercholesterolemic effect using Memecylon edule Roxb. ethanolic extract in cholesterol-induced Swiss albino mice
title_sort evaluation of antihypercholesterolemic effect using memecylon edule roxb. ethanolic extract in cholesterol-induced swiss albino mice
publisher Elsevier
publishDate 2015
url http://umpir.ump.edu.my/id/eprint/29804/1/Evaluation%20of%20antihypercholesterolemic%20effect%20using%20Memecylon%20edule%20Roxb.pdf
http://umpir.ump.edu.my/id/eprint/29804/
https://doi.org/10.1016/j.jacme.2015.09.001
https://doi.org/10.1016/j.jacme.2015.09.001
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