In silico analysis of the antigenic properties of iron-regulated proteins against neisseria meningitides
Neisseria meningitidis is a commensal pathogen that causes infectious cerebrospinal disease in people of all ages. The multivariate role of six disease-causing polysaccharide serotypes is found to play a crucial role in developing vaccines (or general treatment strategies) to treat this emerging pat...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI
2020
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/29984/1/In%20silico%20analysis%20of%20the%20antigenic%20properties%20of%20iron.pdf http://umpir.ump.edu.my/id/eprint/29984/ https://doi.org/10.3390/app10176113 https://doi.org/10.3390/app10176113 |
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| Institution: | Universiti Malaysia Pahang |
| Language: | English |
| Summary: | Neisseria meningitidis is a commensal pathogen that causes infectious cerebrospinal disease in people of all ages. The multivariate role of six disease-causing polysaccharide serotypes is found to play a crucial role in developing vaccines (or general treatment strategies) to treat this emerging pathogen. Iron is a crucial transition metal for N. meningitidis. Proteomic analysis data could be valuable for vaccine design. Here, we conduct a comparative study using computational bioinformatic tools to identify the most effective iron-regulated outer membrane proteins (OMPs) as immunogenic targets for a potential vaccine against N. meningitidis. The basic properties of N. meningitidis OMPs are explored for flexibility, solubility, hydrophilicity, beta-turns, and overall antigenic probability. Results of our study suggest that iron-regulated OMPs are flexible and soluble in water with high densities of conformational B-cell epitopes. As such, they can be recommended as a novel candidate for a vaccine against N. meningitidis both in vitro and in vivo. |
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