Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation

Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation

Abstract. The crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation is presented.The particle size distribution study of CBZ-SAC co-crystals revealed that the multimodal with broad PSD was found for...

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Main Authors: E N, Engku Mat Nasir, F, Ab Rahman, Syarifah, Abd Rahim, R Z, Edros, N., Anuar
Format: Article
Language:English
Published: IOP Publishing Ltd 2020
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/30578/7/Paper%20MKC15002.pdf
http://umpir.ump.edu.my/id/eprint/30578/
https://iopscience.iop.org/issue/1757-899X/736/2
http://doi:10.1088/1757-899X/736/2/022109
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Institution: Universiti Malaysia Pahang
Language: English
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spelling my.ump.umpir.305782021-01-27T06:41:20Z http://umpir.ump.edu.my/id/eprint/30578/ Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation E N, Engku Mat Nasir F, Ab Rahman Syarifah, Abd Rahim R Z, Edros N., Anuar TP Chemical technology Abstract. The crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation is presented.The particle size distribution study of CBZ-SAC co-crystals revealed that the multimodal with broad PSD was found for CBZ concentration of 19.14 mg/ml. Meanwhile, the unimodal with broad PSD were observed at CBZ concentration of 17.01 mg/ml and 17.96 mg/ Crystal characterisation using differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Fourier transform infrared (FTIR) and optical microscopy confirm the solid formed is CBZ-SAC co-crystal Form I with plate-like crystal morphology. IOP Publishing Ltd 2020 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/30578/7/Paper%20MKC15002.pdf E N, Engku Mat Nasir and F, Ab Rahman and Syarifah, Abd Rahim and R Z, Edros and N., Anuar (2020) Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation. IOP Conf. Series: Materials Science and Engineering, 736 (022109). pp. 1-7. ISSN 1757-899X https://iopscience.iop.org/issue/1757-899X/736/2 http://doi:10.1088/1757-899X/736/2/022109
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
E N, Engku Mat Nasir
F, Ab Rahman
Syarifah, Abd Rahim
R Z, Edros
N., Anuar
Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation
description Abstract. The crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation is presented.The particle size distribution study of CBZ-SAC co-crystals revealed that the multimodal with broad PSD was found for CBZ concentration of 19.14 mg/ml. Meanwhile, the unimodal with broad PSD were observed at CBZ concentration of 17.01 mg/ml and 17.96 mg/ Crystal characterisation using differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Fourier transform infrared (FTIR) and optical microscopy confirm the solid formed is CBZ-SAC co-crystal Form I with plate-like crystal morphology.
format Article
author E N, Engku Mat Nasir
F, Ab Rahman
Syarifah, Abd Rahim
R Z, Edros
N., Anuar
author_facet E N, Engku Mat Nasir
F, Ab Rahman
Syarifah, Abd Rahim
R Z, Edros
N., Anuar
author_sort E N, Engku Mat Nasir
title Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation
title_short Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation
title_full Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation
title_fullStr Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation
title_full_unstemmed Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation
title_sort crystallisation parameters effect on the particle size distribution (psd) of carbamazepine-saccharin (cbz-sac) co-crystals in batch cooling crystallisation
publisher IOP Publishing Ltd
publishDate 2020
url http://umpir.ump.edu.my/id/eprint/30578/7/Paper%20MKC15002.pdf
http://umpir.ump.edu.my/id/eprint/30578/
https://iopscience.iop.org/issue/1757-899X/736/2
http://doi:10.1088/1757-899X/736/2/022109
_version_ 1690371151764652032

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