Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System

• Main Authors: Noor Ashila, Ramle, Syarifah, Abd Rahim, El-Hadad, Omar, Nornizar, Anuar
• Format: Article
• Language: English
• Published: Trans Tech Publications, Switzerland 2015
• Subjects: TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/6653/1/solubility_of_carbamazepine-succinic_co-crystal_in_ethanolic_solvent_system.pdf; http://umpir.ump.edu.my/id/eprint/6653/; https://www.scientific.net/AMR.1113.434
• Institution: Universiti Malaysia Pahang Al-Sultan Abdullah

Solubility of carbamazepine co-crystal produced from cooling co-crystallization process with succinic acid as a co-crystal former is investigated in this study. Two techniques are used to determine the solubility of the co-crystal which is gravimetric and HPLC.The solubility experiment in ethanol solvent system were conducted at 6 different temperatures (25, 30, 35, 40, 45 and 50°c) while for succinic acid solution system were conducted at 5 different concentration ratio. Both of the system are equilibrated for 72 hours. Result from the experiment has shown that the solubility of co-crystal is depending on temperature. As the temperature increase, the solubility of co-crystal also increased, this situation meets the Second Law of Thermodynamic which heat facilitates the dissolution process by providing more energy to the system.