Synthesis, Structural Analysis and Screening of Some Novel 5-Substituted Aryl/Aralkyl-1,3,4-Oxadiazol-2-Yl 4-(Morpholin-4-Ylsulfonyl)Benzyl Sulfides as Potential Antibacterial Agents

• Main Authors: Akhtar, Muhammad Nadeem, Rehman, Aziz-ur, Gul, Samreen, Abbasi, Muhammad Athar, Nafeesa, Khadija, Ahmad, Irshad, Afzal, Saira
• Format: Article
• Language: English
• Published: Taylor & Francis 2015
• Subjects: QD Chemistry
• Online Access: http://umpir.ump.edu.my/id/eprint/7989/1/Synthesis%2C%20Structural%20Analysis%2C%20and%20Screening%20of%20Some%20Novel%205-Substituted%20Aryl.pdf; http://umpir.ump.edu.my/id/eprint/7989/; http://dx.doi.org/10.1080/10426507.2014.965816
• Institution: Universiti Malaysia Pahang

A series of new 5-substituted aryl/aralkyl-1,3,4-oxadiazol-2-yl 4-(morpholin-4-ylsulfonyl)benzyl sulfides 6a-k were synthesized by converting multifarious aryl/aralkyl organic acids 1a-k successively into corresponding esters 2a-k, hydrazides 3a-k and 5-substituted aryl/aralkyl-1,3,4-oxadiazole-2-thiols 4a-k. Finally, the target compounds, 6a-k were prepared by stirring 5-substituted-1,3,4-oxadiazole-2-thiols with 4-(4-(bromomethyl)phenylsulfonyl) morpholine (5) in the presence of N,N-dimethylformamide (DMF) and sodium hydride (NaH). The structures of the newly synthesized compounds were elucidated by spectroscopic techniques. In addition, the anti-bacterial activity of all the synthesized compounds was investigated in vitro against Gram-positive and Gram-negative bacteria by using ciprofloxacin as reference standard drug and the results showed that some of the tested compounds possessed good anti-bacterial activity.