α-Glucosidase and α-amylase Inhibitory Constituents of Tinospora crispa: Isolation and Chemical Profile Confirmation by Ultra-high Performance Liquid Chromatography-quadrupole Time-of-flight/mass spectrometry

• Main Authors: Hazrulrizawati, Hamid, M. M., Yusoff, M., Liu, M. R., Karim
• Format: Article
• Language: English; English
• Published: Elsevier Ltd 2015
• Subjects: Q Science (General)
• Online Access: http://umpir.ump.edu.my/id/eprint/9262/1/fist-2015-mashitah-; http://umpir.ump.edu.my/id/eprint/9262/2/a-Glucosidase%20and%20a-amylase%20Inhibitory%20constituents%20of%20Tinospora%20crispa-%20Isolation%20and%20Chemical%20Profile%20Confirmation%20by%20Ultra-High%20Performance%20Liquid%20Chromatography-Quadrupole%20Time-Of-Flight-Mass%20Spectrometry.pdf; http://umpir.ump.edu.my/id/eprint/9262/; http://dx.doi.org/10.1016/j.jff.2015.04.011
• Institution: Universiti Malaysia Pahang

Tinospora crispa has been used in Malaysia to treat diabetes mellitus. We evaluated the effects of compounds isolated from T. crispa vines on the starch digestive enzymes, α-glucosidase and α-amylase. Borapetoside C was the most potent α-glucosidase inhibitor (IC50 = 0.0527 ± 0.008 mg/ml), followed...