Gut-microbiota link in Parkinson’s disease: current perspectives
Parkinson’s disease(PD) is a metacentric neurodegenerative disorder results with accumulation and aggregation of alpha-synculein(α-Syn) (or alpha-synculeinopathy) in the substantia nigra in the central nervous system(CNS).Contributory factors include pesticide exposure, head injury and agriculture...
Saved in:
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
International Organization of Scientific Research
2017
|
Online Access: | https://eprints.ums.edu.my/id/eprint/20299/1/Gut.pdf https://eprints.ums.edu.my/id/eprint/20299/ https://doi.org/10.9790/0853-1601066470 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Universiti Malaysia Sabah |
Language: | English |
id |
my.ums.eprints.20299 |
---|---|
record_format |
eprints |
spelling |
my.ums.eprints.202992018-06-21T05:52:22Z https://eprints.ums.edu.my/id/eprint/20299/ Gut-microbiota link in Parkinson’s disease: current perspectives Murtaza Mustafa Jayaram Menon Kasim Md Mansur Mohammad Illzam Elahee Rajesh Kumar Muniandy Mohd Firdaus Mohd Hayati Fairrul Masnah @ Kadir Sharifa Am Nornazirah Azizan Hud MZ Parkinson’s disease(PD) is a metacentric neurodegenerative disorder results with accumulation and aggregation of alpha-synculein(α-Syn) (or alpha-synculeinopathy) in the substantia nigra in the central nervous system(CNS).Contributory factors include pesticide exposure, head injury and agriculture background. PD has been considered to be a non-genetic disorder, however around 15% individuals with PD have firstdegree relative who has the disease Mutations in genes including SNCA,LRRK2 and gluococerebrosidase (GBA) found to be risk factor for sporadic PD. Brain cells could be lost due to an abnormal accumulation of the protein alpha-synculein.This insoluble protein accumulates inside neurons forming inclusions called Lewy bodies. Other cell death mechanisms include proteasomal and lysosomal system dysfunction, but the mechanisms are not fully understood. Brain –gut axis(GBA) refers to central nervous system(CNS) control of the enteric nervous system(ENS) through vagus nerve intervention. PD is characterized by alphasynculeinopathy affecting all levels of the brain-gut axis.Both clinical and neuropathological evidences indicate the neurodegenerative changes in PD are accompanied by gastrointestinal symptoms that may precede or follow the central nervous systemimpairment. Frequent symptoms in PD include tremor, rigidity, slowness of movement and difficulty with walking. Treatment with L-DOPA(levodopa),with dopamine agonist, medications become less effective and produce complications. Research studies recommend new therapeutic approach in PD based on modification of the gut microbiota with probiotics, prebiotics, or even fecal microbiota transplantation. International Organization of Scientific Research 2017-01 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/20299/1/Gut.pdf Murtaza Mustafa and Jayaram Menon and Kasim Md Mansur and Mohammad Illzam Elahee and Rajesh Kumar Muniandy and Mohd Firdaus Mohd Hayati and Fairrul Masnah @ Kadir and Sharifa Am and Nornazirah Azizan and Hud MZ (2017) Gut-microbiota link in Parkinson’s disease: current perspectives. Journal of Dental and Medical Sciences, 16 (1). pp. 64-70. ISSN 2279-0861 https://doi.org/10.9790/0853-1601066470 |
institution |
Universiti Malaysia Sabah |
building |
UMS Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Malaysia Sabah |
content_source |
UMS Institutional Repository |
url_provider |
http://eprints.ums.edu.my/ |
language |
English |
description |
Parkinson’s disease(PD) is a metacentric neurodegenerative disorder results with accumulation and
aggregation of alpha-synculein(α-Syn) (or alpha-synculeinopathy) in the substantia nigra in the central
nervous system(CNS).Contributory factors include pesticide exposure, head injury and agriculture background.
PD has been considered to be a non-genetic disorder, however around 15% individuals with PD have firstdegree
relative who has the disease Mutations in genes including SNCA,LRRK2 and gluococerebrosidase
(GBA) found to be risk factor for sporadic PD. Brain cells could be lost due to an abnormal accumulation of the
protein alpha-synculein.This insoluble protein accumulates inside neurons forming inclusions called Lewy
bodies. Other cell death mechanisms include proteasomal and lysosomal system dysfunction, but the
mechanisms are not fully understood. Brain –gut axis(GBA) refers to central nervous system(CNS) control of
the enteric nervous system(ENS) through vagus nerve intervention. PD is characterized by alphasynculeinopathy
affecting all levels of the brain-gut axis.Both clinical and neuropathological evidences indicate
the neurodegenerative changes in PD are accompanied by gastrointestinal symptoms that may precede or
follow the central nervous systemimpairment. Frequent symptoms in PD include tremor, rigidity, slowness of
movement and difficulty with walking. Treatment with L-DOPA(levodopa),with dopamine agonist, medications
become less effective and produce complications. Research studies recommend new therapeutic approach in PD
based on modification of the gut microbiota with probiotics, prebiotics, or even fecal microbiota
transplantation. |
format |
Article |
author |
Murtaza Mustafa Jayaram Menon Kasim Md Mansur Mohammad Illzam Elahee Rajesh Kumar Muniandy Mohd Firdaus Mohd Hayati Fairrul Masnah @ Kadir Sharifa Am Nornazirah Azizan Hud MZ |
spellingShingle |
Murtaza Mustafa Jayaram Menon Kasim Md Mansur Mohammad Illzam Elahee Rajesh Kumar Muniandy Mohd Firdaus Mohd Hayati Fairrul Masnah @ Kadir Sharifa Am Nornazirah Azizan Hud MZ Gut-microbiota link in Parkinson’s disease: current perspectives |
author_facet |
Murtaza Mustafa Jayaram Menon Kasim Md Mansur Mohammad Illzam Elahee Rajesh Kumar Muniandy Mohd Firdaus Mohd Hayati Fairrul Masnah @ Kadir Sharifa Am Nornazirah Azizan Hud MZ |
author_sort |
Murtaza Mustafa |
title |
Gut-microbiota link in Parkinson’s disease: current perspectives |
title_short |
Gut-microbiota link in Parkinson’s disease: current perspectives |
title_full |
Gut-microbiota link in Parkinson’s disease: current perspectives |
title_fullStr |
Gut-microbiota link in Parkinson’s disease: current perspectives |
title_full_unstemmed |
Gut-microbiota link in Parkinson’s disease: current perspectives |
title_sort |
gut-microbiota link in parkinson’s disease: current perspectives |
publisher |
International Organization of Scientific Research |
publishDate |
2017 |
url |
https://eprints.ums.edu.my/id/eprint/20299/1/Gut.pdf https://eprints.ums.edu.my/id/eprint/20299/ https://doi.org/10.9790/0853-1601066470 |
_version_ |
1760229696314802176 |