Influence of process variables and formulation composition on sphericity and diameter of Ca-alginate-chitosan liquid core capsule prepared by extrusion dripping method

The influence of process variables and formulation composition on the sphericity and diameter of the alginate capsules which contained dual cations (Ca-and-chitosan) are characterized in this study. Capsule sphericty was not influenced by needle diameter but instead, capsule diameter increased propo...

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Main Authors: Gim, Pao Lim, Lee, Boon Beng, Muhammad Syarhabil Ahmad, Harbant Singh, Ravindra Pogaku
Format: Article
Language:English
Published: 2016
Subjects:
Online Access:https://eprints.ums.edu.my/id/eprint/21518/1/Influence%20of%20process%20variables%20and%20formulation%20composition%20on%20sphericity%20and%20diameter%20of%20Ca-alginate-chitosan%20liquid%20core%20capsule%20prepared%20by%20extrusion%20dripping%20method.pdf
https://eprints.ums.edu.my/id/eprint/21518/
https://doi.org/10.1080/02726351.2015.1107160
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Institution: Universiti Malaysia Sabah
Language: English
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spelling my.ums.eprints.215182019-03-08T08:09:41Z https://eprints.ums.edu.my/id/eprint/21518/ Influence of process variables and formulation composition on sphericity and diameter of Ca-alginate-chitosan liquid core capsule prepared by extrusion dripping method Gim, Pao Lim Lee, Boon Beng Muhammad Syarhabil Ahmad Harbant Singh Ravindra Pogaku Q Science (General) QD Chemistry The influence of process variables and formulation composition on the sphericity and diameter of the alginate capsules which contained dual cations (Ca-and-chitosan) are characterized in this study. Capsule sphericty was not influenced by needle diameter but instead, capsule diameter increased proportionally with the needle diameter. The combined effects of the liquid core solution and alginate solution on the sphericity of the capsules are tabulated. Spherical capsules can be produced when the following criteria were fulfilled: stirring speed is in the range of 240–300 rpm; calcium chloride concentration is >5 g/L; viscosity of liquid core solution is >203 mPa.s; as well as viscosity of alginate solution is in between 47 and 386 mPa.s. The capsule diameter was predicted using a modified Tate’s law equation and an error analysis was conducted to evaluate the equation. The predicted diameter was well correlated with the experimental data with an average absolute deviation <3.6%. 2016 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/21518/1/Influence%20of%20process%20variables%20and%20formulation%20composition%20on%20sphericity%20and%20diameter%20of%20Ca-alginate-chitosan%20liquid%20core%20capsule%20prepared%20by%20extrusion%20dripping%20method.pdf Gim, Pao Lim and Lee, Boon Beng and Muhammad Syarhabil Ahmad and Harbant Singh and Ravindra Pogaku (2016) Influence of process variables and formulation composition on sphericity and diameter of Ca-alginate-chitosan liquid core capsule prepared by extrusion dripping method. Particulate Science and Technology, 34 (6). pp. 681-690. https://doi.org/10.1080/02726351.2015.1107160
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
topic Q Science (General)
QD Chemistry
spellingShingle Q Science (General)
QD Chemistry
Gim, Pao Lim
Lee, Boon Beng
Muhammad Syarhabil Ahmad
Harbant Singh
Ravindra Pogaku
Influence of process variables and formulation composition on sphericity and diameter of Ca-alginate-chitosan liquid core capsule prepared by extrusion dripping method
description The influence of process variables and formulation composition on the sphericity and diameter of the alginate capsules which contained dual cations (Ca-and-chitosan) are characterized in this study. Capsule sphericty was not influenced by needle diameter but instead, capsule diameter increased proportionally with the needle diameter. The combined effects of the liquid core solution and alginate solution on the sphericity of the capsules are tabulated. Spherical capsules can be produced when the following criteria were fulfilled: stirring speed is in the range of 240–300 rpm; calcium chloride concentration is >5 g/L; viscosity of liquid core solution is >203 mPa.s; as well as viscosity of alginate solution is in between 47 and 386 mPa.s. The capsule diameter was predicted using a modified Tate’s law equation and an error analysis was conducted to evaluate the equation. The predicted diameter was well correlated with the experimental data with an average absolute deviation <3.6%.
format Article
author Gim, Pao Lim
Lee, Boon Beng
Muhammad Syarhabil Ahmad
Harbant Singh
Ravindra Pogaku
author_facet Gim, Pao Lim
Lee, Boon Beng
Muhammad Syarhabil Ahmad
Harbant Singh
Ravindra Pogaku
author_sort Gim, Pao Lim
title Influence of process variables and formulation composition on sphericity and diameter of Ca-alginate-chitosan liquid core capsule prepared by extrusion dripping method
title_short Influence of process variables and formulation composition on sphericity and diameter of Ca-alginate-chitosan liquid core capsule prepared by extrusion dripping method
title_full Influence of process variables and formulation composition on sphericity and diameter of Ca-alginate-chitosan liquid core capsule prepared by extrusion dripping method
title_fullStr Influence of process variables and formulation composition on sphericity and diameter of Ca-alginate-chitosan liquid core capsule prepared by extrusion dripping method
title_full_unstemmed Influence of process variables and formulation composition on sphericity and diameter of Ca-alginate-chitosan liquid core capsule prepared by extrusion dripping method
title_sort influence of process variables and formulation composition on sphericity and diameter of ca-alginate-chitosan liquid core capsule prepared by extrusion dripping method
publishDate 2016
url https://eprints.ums.edu.my/id/eprint/21518/1/Influence%20of%20process%20variables%20and%20formulation%20composition%20on%20sphericity%20and%20diameter%20of%20Ca-alginate-chitosan%20liquid%20core%20capsule%20prepared%20by%20extrusion%20dripping%20method.pdf
https://eprints.ums.edu.my/id/eprint/21518/
https://doi.org/10.1080/02726351.2015.1107160
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