Engineered mycobacterium tuberculosis antigen assembly into core-shell nanobeads for diagnosis of tuberculosis

• Main Authors: Nurul Syahidah Sheffee, Patricia Rubio-Reyes, Mayelin Mirabal, Romel Calero, Humberto Carrillo-Calvet, Shuxiong Chen, Chin, Kai Ling, Nur Atiqah Syairah Shakimi, Fadhilah Zulkipli Anis, Siti Suraiya, Maria E. Sarmiento, Mohd Nor Norazmi, Armando Acosta, Bernd H.A. Rehm
• Format: Article
• Language: English; English
• Published: Elsevier Inc. 2021
• Subjects: R Medicine (General); RB Pathology
• Online Access: https://eprints.ums.edu.my/id/eprint/27284/1/Engineered%20mycobacterium%20tuberculosis%20antigen%20assembly%20into%20core-shell%20nanobeads%20for%20diagnosis%20of%20tuberculosis%20FULL%20TEXT.pdf; https://eprints.ums.edu.my/id/eprint/27284/2/Engineered%20mycobacterium%20tuberculosis%20antigen%20assembly%20into%20core-shell%20nanobeads%20for%20diagnosis%20of%20tuberculosis%20ABSTRACT.pdf; https://eprints.ums.edu.my/id/eprint/27284/; https://www.sciencedirect.com/science/article/pii/S1549963421000174?casa_token=yBNTAZGBt94AAAAA:Aipr5TiGUOFLKAXcA3uQqhAV9k3zp0K6FL6BkT62LH1Tsd-VrV2aRZvj6j959onYWFhKQOdId-Ml
• Institution: Universiti Malaysia Sabah

Despite recent advances in diagnosis, tuberculosis (TB) remains one of the ten leading causes of death worldwide. Here, we engineered Mycobacterium tuberculosis (Mtb) proteins (ESAT6, CFP10, and MTB7.7) to self-assemble into core-shell nanobeads for enhanced TB diagnosis. Respective purified Mtb ant...