Cryptogenic cirrhosis, an ambiguity of a diagnosis a case report of progressive cirrhosis of undetermined cause

• Main Authors: Alvin Oliver Payus, Justin Leow Wen Hsiang, Ong Hui Yun, Neeraj Vinayakumar
• Format: Article
• Language: English; English
• Published: University of the Philippines Manila 2021
• Subjects: QM1-695 Human anatomy; RC799-869 Diseases of the digestive system. Gastroenterology
• Online Access: https://eprints.ums.edu.my/id/eprint/30762/1/Cryptogenic%20cirrhosis%2C%20an%20ambiguity%20of%20a%20diagnosis%20a%20case%20report%20of%20progressive%20cirrhosis%20of%20undetermined%20cause-ABSTRACT.pdf; https://eprints.ums.edu.my/id/eprint/30762/2/Cryptogenic%20cirrhosis%2C%20an%20ambiguity%20of%20a%20diagnosis%20a%20case%20report%20of%20progressive%20cirrhosis%20of%20undetermined%20cause.pdf; https://eprints.ums.edu.my/id/eprint/30762/; https://actamedicaphilippina.upm.edu.ph/index.php/acta/article/view/1747; https://doi.org/10.47895/amp.vi0.1747
• Institution: Universiti Malaysia Sabah

Cirrhosis is the result of chronic liver disease due to a variety of causes. It is deemed to be cryptogenic when the leading cause cannot be identified despite extensive laboratory, radiological and pathological investigations. The prevalence of cryptogenic cirrhosis diagnosis has been dramatically reduced in recent years due to the advanced achievement in diagnostic medicine, whereby it is attributed to only about less than 5% of cirrhosis cases. Here, we present a case of a 16-year-old boy with nonsignificant family history, was not taking any regular medication, and presented with progressive intermittent jaundice for a few years due to liver cirrhosis. Although an extensive investigation has been done, the etiology of the cirrhotic liver was still unknown. He had no features to support nonalcoholic steatohepatitis. He was in Child’s Grade B and prophylactically treated with a regular dose of propranolol to prevent portal hypertension complication while waiting for a liver transplant. This case report served the objective of showing that despite the advances in medical diagnostic techniques, cryptogenic cirrhosis is still used as a diagnosis in cases of chronic liver disease of unknown etiology.