Synthesis of Functionalized Thiophene Based Pyrazole Amides via Various Catalytic Approaches: Structural Features through Computational Applications and Nonlinear Optical Properties

• Main Authors: Iram Kanwal, Nasir Rasool, Syeda Huda Mehdi Zaidi, Zainul Amiruddin Zakaria, Muhammad Bilal, Muhammad Ali Hashmi, Adeel Mubarik, Gulraiz Ahmad, Syed Adnan Ali Shah
• Format: Article
• Language: English; English
• Published: Molecular Diversity Preservation International 2022
• Subjects: QD1-999 Chemistry; R5-920 Medicine (General)
• Online Access: https://eprints.ums.edu.my/id/eprint/32798/1/Synthesis%20of%20Functionalized%20Thiophene%20Based%20Pyrazole%20Amides%20via%20Various%20Catalytic%20Approaches.pdf; https://eprints.ums.edu.my/id/eprint/32798/2/Synthesis%20of%20Functionalized%20Thiophene%20Based%20Pyrazole%20Amides%20via%20Various%20Catalytic%20Approaches1.pdf; https://eprints.ums.edu.my/id/eprint/32798/; https://www.mdpi.com/1420-3049/27/2/360; https://doi.org/10.3390/molecules27020360
• Institution: Universiti Malaysia Sabah

In the present study, pyrazole-thiophene-based amide derivatives were synthesized by different methodologies. Here, 5-Bromothiophene carboxylic acid (2) was reacted with substituted, unsubstituted, and protected pyrazole to synthesize the amide. It was observed that unsubstituted amide (5-bromo-N-(5...