Cytokine (Il-10, il-6, tnf-a and tgf-ß1) gene polymorphisms in chronic hepatitis c virus infection among Malay male drug abusers

• Main Authors: Che Ismail Che Noh, Imran Ahmad, Siti Suraiya, Nur Fadhlina Musa, Asma Abdullah Nurul, Abu Bakar Ruzilawati
• Format: Article
• Language: English; English
• Published: Multidisciplinary Digital Publishing Institute (MDPI) 2021
• Subjects: HV5800-5840 Drug habits. Drug abuse
• Online Access: https://eprints.ums.edu.my/id/eprint/33081/1/Cytokine%20%28Il-10%2C%20il-6%2C%20tnf-a%20and%20tgf-%C3%9F1%29%20gene%20polymorphisms%20in%20chronic%20hepatitis%20c%20virus%20infection%20among%20Malay%20male%20drug%20abusers.pdf; https://eprints.ums.edu.my/id/eprint/33081/2/Cytokine%20%28Il-10%2C%20il-6%2C%20tnf-a%20and%20tgf-%C3%9F1%29%20gene%20polymorphisms%20in%20chronic%20hepatitis%20c%20virus%20infection%20among%20Malay%20male%20drug%20abusers_ABSTRACT.pdf; https://eprints.ums.edu.my/id/eprint/33081/; https://www.mdpi.com/2227-9059/9/9/1115/htm; https://doi.org/10.3390/biomedicines9091115
• Institution: Universiti Malaysia Sabah

Cytokines play an important role in modulating inflammation during viral infection, including hepatitis C virus (HCV) infection. Genetic polymorphisms of cytokines can alter the immune response against this infection. The objective of this study was to investigate the possible association between chronic hepatitis C virus infection susceptibility and cytokine gene polymorphism for interleukin-10 (IL-10) rs1800896 and rs1800871, interleukin 6 (IL-6) rs1800795, TNF-α rs1800629, and TGF-β1 rs1800471 in Malay male drug abusers. The study was conducted on 76 HCV-positive (HP) male drug abusers and 40 controls (HCV-negative male drug abusers). We found that there were significant differences in the frequencies of genotype for IL-10 rs1800871 (p = 0.0386) and at the allelic level for IL-10 rs1800896 A versus G allele (p = 0.0142) between the HP group and the control group. However, there were no significant differences in gene polymorphism in interleukin 6 rs1800795, TNF-α rs1800629 and TGF-β1 rs1800471. These findings suggest significant associations between gene polymorphism for IL-10 rs1800871, IL-10 rs1800896 (at the allelic level) and susceptibility to HCV infection among Malay male drug abusers.