Facile Synthesis of Functionalized Phenoxy Quinolines: Antibacterial Activities against ESBL Producing Escherichia coli and MRSA, Docking Studies, and Structural Features Determination through Computational Approach

• Main Authors: Mahwish Arshad, Nasir Rasool, Muhammad Usman Qamar, Syed Adnan Ali Shah, Zainul Amiruddin Zakaria
• Format: Article
• Language: English; English
• Published: Multidisciplinary Digital Publishing Institute (MDPI) 2022
• Subjects: QR1-502 Microbiology; RC109-216 Infectious and parasitic diseases
• Online Access: https://eprints.ums.edu.my/id/eprint/34167/1/FULL%20TEXT.pdf; https://eprints.ums.edu.my/id/eprint/34167/3/ABSTRACT.pdf; https://eprints.ums.edu.my/id/eprint/34167/; https://www.mdpi.com/1420-3049/27/12/3732/htm; https://doi.org/10.3390/molecules27123732
• Institution: Universiti Malaysia Sabah

The synthesis of new 6-Bromoquinolin-4-ol derivatives (3a–3h) by Chan–Lam coupling utilizing different types of solvents (protic, aprotic, and mixed solvents) and bases was studied in the present manuscript. Furthermore, their potential against ESBL producing Escherichia coli (ESBL E. coli) and meth...