Insight into the possible mechanism(s) involved in the antinociceptive and antineuropathic activity of Descurainia sophia L. Webb ex Prantl essential oil

Ethnopharmacological relevance: Descurainia sophia (L.)(Brassicaceae), popularly known as “Khaksheer”, is a native species widely distributed in Iran. The seeds and essential oil has been used in local traditional medicine (Persian folk ethnomedicine) to treat fever, inflammation, back pain, and hea...

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Main Authors: Donya Ziafatdoost Abed, Sajjad Jabbari, Zainul Amiruddin Zakaria, Saeed Mohammadi
Format: Article
Language:English
English
Published: Elsevier Ireland Ltd 2022
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Online Access:https://eprints.ums.edu.my/id/eprint/34805/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/34805/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/34805/
https://www.sciencedirect.com/science/article/abs/pii/S0378874122006778
https://doi.org/10.1016/j.jep.2022.115638
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Institution: Universiti Malaysia Sabah
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spelling my.ums.eprints.348052022-11-10T13:02:44Z https://eprints.ums.edu.my/id/eprint/34805/ Insight into the possible mechanism(s) involved in the antinociceptive and antineuropathic activity of Descurainia sophia L. Webb ex Prantl essential oil Donya Ziafatdoost Abed Sajjad Jabbari Zainul Amiruddin Zakaria Saeed Mohammadi RS153-441 Materia medica Ethnopharmacological relevance: Descurainia sophia (L.)(Brassicaceae), popularly known as “Khaksheer”, is a native species widely distributed in Iran. The seeds and essential oil has been used in local traditional medicine (Persian folk ethnomedicine) to treat fever, inflammation, back pain, and headache. Aim of the study: To investigate in vitro anti-nociceptive and antineuropathic activities of Descurainia sophia seeds essential oil (DSEO) in rats and to determine the possible mechanism(s) involved. Materials and methods: The antinociceptive activity of DSEO or Linolenic acid (LA) was evaluated using the formalin induced paw licking test followed by determination on the role of NO-cGMP-K+ channel pathway as well as a number of non-opioid receptor systems (vanilloid, dopamine, cannabinoid, serotonin, peroxisome proliferator activated, and adrenergic receptors) in the modulation of DSEO-induced antinociceptive activity. Additionally, the cervical spinal cord contusion (CCS) model was used to study antineuropathic potential of DSEO or LA. Results: DSEO exerted significant (p < 0.05) antinociceptive activity in formalin test (both phases) and altered mechanical allodynia and hyperalgesia observed in the CCS model. Pretreatment with glibenclamide, Nω-nitro-L-arginine methyl ester, tranilast, methylene blue, SCH23390, SR141716A and SR144528 restored DSEO-induced antinociceptive activity observed in the formalin test. Furthermore, LA also reduced nociceptive responses induced in the formalin and CCS models. Conclusion: DSEO inhibits inflammatory mediated nociceptive response partly via the modulation of NO-cGMP-K+ channels pathway well as the activation of vanilloid, dopamine, and cannabinoid receptors, and exerts antineuropathic activity possibly via the modulation of inflammatory mediated activity. Thus, these findings confirm the Persian ethno-medicine claim on the efficacy of D. Sophia. Elsevier Ireland Ltd 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/34805/2/FULL%20TEXT.pdf text en https://eprints.ums.edu.my/id/eprint/34805/1/ABSTRACT.pdf Donya Ziafatdoost Abed and Sajjad Jabbari and Zainul Amiruddin Zakaria and Saeed Mohammadi (2022) Insight into the possible mechanism(s) involved in the antinociceptive and antineuropathic activity of Descurainia sophia L. Webb ex Prantl essential oil. Journal of Ethnopharmacology, 298 (115638). pp. 1-9. ISSN 0378-8741 https://www.sciencedirect.com/science/article/abs/pii/S0378874122006778 https://doi.org/10.1016/j.jep.2022.115638
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic RS153-441 Materia medica
spellingShingle RS153-441 Materia medica
Donya Ziafatdoost Abed
Sajjad Jabbari
Zainul Amiruddin Zakaria
Saeed Mohammadi
Insight into the possible mechanism(s) involved in the antinociceptive and antineuropathic activity of Descurainia sophia L. Webb ex Prantl essential oil
description Ethnopharmacological relevance: Descurainia sophia (L.)(Brassicaceae), popularly known as “Khaksheer”, is a native species widely distributed in Iran. The seeds and essential oil has been used in local traditional medicine (Persian folk ethnomedicine) to treat fever, inflammation, back pain, and headache. Aim of the study: To investigate in vitro anti-nociceptive and antineuropathic activities of Descurainia sophia seeds essential oil (DSEO) in rats and to determine the possible mechanism(s) involved. Materials and methods: The antinociceptive activity of DSEO or Linolenic acid (LA) was evaluated using the formalin induced paw licking test followed by determination on the role of NO-cGMP-K+ channel pathway as well as a number of non-opioid receptor systems (vanilloid, dopamine, cannabinoid, serotonin, peroxisome proliferator activated, and adrenergic receptors) in the modulation of DSEO-induced antinociceptive activity. Additionally, the cervical spinal cord contusion (CCS) model was used to study antineuropathic potential of DSEO or LA. Results: DSEO exerted significant (p < 0.05) antinociceptive activity in formalin test (both phases) and altered mechanical allodynia and hyperalgesia observed in the CCS model. Pretreatment with glibenclamide, Nω-nitro-L-arginine methyl ester, tranilast, methylene blue, SCH23390, SR141716A and SR144528 restored DSEO-induced antinociceptive activity observed in the formalin test. Furthermore, LA also reduced nociceptive responses induced in the formalin and CCS models. Conclusion: DSEO inhibits inflammatory mediated nociceptive response partly via the modulation of NO-cGMP-K+ channels pathway well as the activation of vanilloid, dopamine, and cannabinoid receptors, and exerts antineuropathic activity possibly via the modulation of inflammatory mediated activity. Thus, these findings confirm the Persian ethno-medicine claim on the efficacy of D. Sophia.
format Article
author Donya Ziafatdoost Abed
Sajjad Jabbari
Zainul Amiruddin Zakaria
Saeed Mohammadi
author_facet Donya Ziafatdoost Abed
Sajjad Jabbari
Zainul Amiruddin Zakaria
Saeed Mohammadi
author_sort Donya Ziafatdoost Abed
title Insight into the possible mechanism(s) involved in the antinociceptive and antineuropathic activity of Descurainia sophia L. Webb ex Prantl essential oil
title_short Insight into the possible mechanism(s) involved in the antinociceptive and antineuropathic activity of Descurainia sophia L. Webb ex Prantl essential oil
title_full Insight into the possible mechanism(s) involved in the antinociceptive and antineuropathic activity of Descurainia sophia L. Webb ex Prantl essential oil
title_fullStr Insight into the possible mechanism(s) involved in the antinociceptive and antineuropathic activity of Descurainia sophia L. Webb ex Prantl essential oil
title_full_unstemmed Insight into the possible mechanism(s) involved in the antinociceptive and antineuropathic activity of Descurainia sophia L. Webb ex Prantl essential oil
title_sort insight into the possible mechanism(s) involved in the antinociceptive and antineuropathic activity of descurainia sophia l. webb ex prantl essential oil
publisher Elsevier Ireland Ltd
publishDate 2022
url https://eprints.ums.edu.my/id/eprint/34805/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/34805/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/34805/
https://www.sciencedirect.com/science/article/abs/pii/S0378874122006778
https://doi.org/10.1016/j.jep.2022.115638
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