Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection
Link to publisher's homepage at http://www.groupes.polymtl.ca/jnmes/
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Journal of New Materials for Electrochemical Systems
2011
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my.unimap-133062016-06-12T14:47:06Z Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection T.S., Dhahi Uda, Hashim, Prof. Dr. N.M., Ahmed H., Nazma Nano-gap Biosensor DNA Gold electrode Hybridization Immobilization Link to publisher's homepage at http://www.groupes.polymtl.ca/jnmes/ We develop a method for fabricating the nano-gaps directly by using just photolithography and wet etching processes without any nano lithography or difficult techniques. It shows that this resolution enhancement allows one to fabricate metal electrodes with separation from arbitrarily large to fewer than one hundred nanometers. Furthermore, because these nano-gaps are on a thin film, they can be imaged with high-resolution transmission electron microscopy (HRTEM). Efforts toward achieving electrical contact to nanostructures have been active for over a decade. Even though several devices based on "nano-gaps" - two gaps separated by a nanometer-scale distance - have been demonstrated, their realization has remained a significant challenge. Even the best methods are highly labor-intensive and suffer from low yield and poor geometrical control. Most nano-gaps are also incompatible with high resolution transmission electron microscopy (HRTEM) and scanning electron microscopy (SEM). As a consequence, the proof of the nano-gap quality and content in past studies has been indirect. High-resolution imaging is therefore required to ensure the quality of nano-gaps and to be able to identify possible artifacts. This project presents a unique vertical nano-gap biosensor that can detect changes in DNA structure. Using a size reduction to interrogate samples between the nano-scale gaps, this biosensor will be sensitive enough to record the conformational changes for ss- DNA. 2011-07-22T01:28:16Z 2011-07-22T01:28:16Z 2011 Article Journal of New Materials for Electrochemical Systems, Vol. 14(3), 2011, pages 191-196 1480-2422 http://www.groupes.polymtl.ca/jnmes/modules/journal/index.php/content0296.html http://hdl.handle.net/123456789/13306 en Journal of New Materials for Electrochemical Systems |
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English |
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Nano-gap Biosensor DNA Gold electrode Hybridization Immobilization |
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Nano-gap Biosensor DNA Gold electrode Hybridization Immobilization T.S., Dhahi Uda, Hashim, Prof. Dr. N.M., Ahmed H., Nazma Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection |
| description |
Link to publisher's homepage at http://www.groupes.polymtl.ca/jnmes/ |
| format |
Article |
| author |
T.S., Dhahi Uda, Hashim, Prof. Dr. N.M., Ahmed H., Nazma |
| author_facet |
T.S., Dhahi Uda, Hashim, Prof. Dr. N.M., Ahmed H., Nazma |
| author_sort |
T.S., Dhahi |
| title |
Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection |
| title_short |
Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection |
| title_full |
Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection |
| title_fullStr |
Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection |
| title_full_unstemmed |
Fabrication and characterization of gold nano-gaps for ssDNA immobilization and hybridization detection |
| title_sort |
fabrication and characterization of gold nano-gaps for ssdna immobilization and hybridization detection |
| publisher |
Journal of New Materials for Electrochemical Systems |
| publishDate |
2011 |
| url |
http://dspace.unimap.edu.my/xmlui/handle/123456789/13306 |
| _version_ |
1643790811628830720 |