Improved solubility of hydrophobic drugs using hot melt extrusion technology
The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012) jointly organized by Universiti Malaysia Perlis and Athlone Institute of Technology in collaboration with The Ministry of Higher Education (MOHE) Malaysia, Education Malaysia and Malaysia Po...
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Universiti Malaysia Perlis (UniMAP)
2013
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my.unimap-308342013-12-24T13:13:44Z Improved solubility of hydrophobic drugs using hot melt extrusion technology Kenny, Elaine Hydrophobic drugs Hot melt extrusion technology Bioavailability The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012) jointly organized by Universiti Malaysia Perlis and Athlone Institute of Technology in collaboration with The Ministry of Higher Education (MOHE) Malaysia, Education Malaysia and Malaysia Postgraduates Student Association Ireland (MyPSI), 18th - 19th June 2012 at Putra World Trade Center (PWTC), Kuala Lumpur, Malaysia It is estimated that about 40% of all new chemical entities have poor bioavailability because of low aqueous solubility. This percentage still increases due to combinatorial chemistry and the impact of lipophilic receptors1. Solubility is essential for the therapeutic effectiveness of the drug, independent of the route of administration. Poorly soluble drugs are often a challenging task for formulators in the industry. Conventional approaches for enhancement of solubility have limited applicability, especially when the drugs are poorly soluble simultaneously in aqueous and in non-aqueous media. Solubilisation may be affected by co-solvent water interaction, micellar solubilisation, reduction in particle size, inclusion complexes, solid dispersion, and change in polymorph 2013-12-24T13:13:44Z 2013-12-24T13:13:44Z 2012-06-18 Other p. 1284 978-967-5760-11-2 http://hdl.handle.net/123456789/30834 en The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012); Universiti Malaysia Perlis (UniMAP) |
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Hydrophobic drugs Hot melt extrusion technology Bioavailability |
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Hydrophobic drugs Hot melt extrusion technology Bioavailability Kenny, Elaine Improved solubility of hydrophobic drugs using hot melt extrusion technology |
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The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012) jointly organized by Universiti Malaysia Perlis and Athlone Institute of Technology in collaboration with The Ministry of Higher Education (MOHE) Malaysia, Education Malaysia and Malaysia Postgraduates Student Association Ireland (MyPSI), 18th - 19th June 2012 at Putra World Trade Center (PWTC), Kuala Lumpur, Malaysia |
| format |
Other |
| author |
Kenny, Elaine |
| author_facet |
Kenny, Elaine |
| author_sort |
Kenny, Elaine |
| title |
Improved solubility of hydrophobic drugs using hot melt extrusion technology |
| title_short |
Improved solubility of hydrophobic drugs using hot melt extrusion technology |
| title_full |
Improved solubility of hydrophobic drugs using hot melt extrusion technology |
| title_fullStr |
Improved solubility of hydrophobic drugs using hot melt extrusion technology |
| title_full_unstemmed |
Improved solubility of hydrophobic drugs using hot melt extrusion technology |
| title_sort |
improved solubility of hydrophobic drugs using hot melt extrusion technology |
| publisher |
Universiti Malaysia Perlis (UniMAP) |
| publishDate |
2013 |
| url |
http://dspace.unimap.edu.my/xmlui/handle/123456789/30834 |
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1643796390556467200 |