Membrane crystallization for the recovery of a pharmaceutical compound from waste streams
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2014
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my.unimap-327732014-03-15T03:06:28Z Membrane crystallization for the recovery of a pharmaceutical compound from waste streams Brito Martínez, M. Nora, Jullok Rodríguez Negrín, Z. Van der Bruggen, B. Luis, P. patricia.luis@uclouvain.be Membrane crystallization Active pharmaceutical ingredient Vitrofural Aqueous waste streams Mass transfer coefficients Economic evaluation Link to publisher's homepage at http://www.elsevier.com The recovery of the active pharmaceutical compound 1-(5-bromo-fur-2-il)-2-bromo-2-nitroethane (denoted as G-1) in a crystalline form from waste aqueous solutions using membrane crystallization is addressed in this work. The process conditions were evaluated, observing that a low flowrate of the feed solution (5.0 ml/min) is required to crystallize G-1. In addition, the use of Vitrofural as the feed solution, which is a mixture of G-1 and PEG, allows operating with higher concentrations due to the higher solubility of Vitrofural in water. However, the presence of PEG affects the mass transfer, leading to a lower transmembrane flux compared to the use of pure G-1. SEM images were used to evaluate the surface morphology of the crystallized G-1. It was concluded that the crystals obtained by membrane crystallization have the same morphology as the commercial G-1. Thus, the application of membrane crystallization for G-1 recovery can be considered as a novel technique with high potential to recover pharmaceutical compounds from waste streams. 2014-03-15T03:06:28Z 2014-03-15T03:06:28Z 2014-02 Article Chemical Engineering Research and Design, vol.92 (2), 2014, pages 264–272 0263-8762 http://dspace.unimap.edu.my:80/dspace/handle/123456789/32773 http://www.sciencedirect.com/science/article/pii/S0263876213003262 http://dx.doi.org/10.1016/j.cherd.2013.07.029 en Elsevier |
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| language |
English |
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Membrane crystallization Active pharmaceutical ingredient Vitrofural Aqueous waste streams Mass transfer coefficients Economic evaluation |
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Membrane crystallization Active pharmaceutical ingredient Vitrofural Aqueous waste streams Mass transfer coefficients Economic evaluation Brito Martínez, M. Nora, Jullok Rodríguez Negrín, Z. Van der Bruggen, B. Luis, P. Membrane crystallization for the recovery of a pharmaceutical compound from waste streams |
| description |
Link to publisher's homepage at http://www.elsevier.com |
| author2 |
patricia.luis@uclouvain.be |
| author_facet |
patricia.luis@uclouvain.be Brito Martínez, M. Nora, Jullok Rodríguez Negrín, Z. Van der Bruggen, B. Luis, P. |
| format |
Article |
| author |
Brito Martínez, M. Nora, Jullok Rodríguez Negrín, Z. Van der Bruggen, B. Luis, P. |
| author_sort |
Brito Martínez, M. |
| title |
Membrane crystallization for the recovery of a pharmaceutical compound from waste streams |
| title_short |
Membrane crystallization for the recovery of a pharmaceutical compound from waste streams |
| title_full |
Membrane crystallization for the recovery of a pharmaceutical compound from waste streams |
| title_fullStr |
Membrane crystallization for the recovery of a pharmaceutical compound from waste streams |
| title_full_unstemmed |
Membrane crystallization for the recovery of a pharmaceutical compound from waste streams |
| title_sort |
membrane crystallization for the recovery of a pharmaceutical compound from waste streams |
| publisher |
Elsevier |
| publishDate |
2014 |
| url |
http://dspace.unimap.edu.my:80/dspace/handle/123456789/32773 |
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1643796980948795392 |