The relationship between age and the manifestations of and mortality associated with severe malaria.
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Oxford University Press
2014
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my.unimap-335782014-04-10T02:35:06Z The relationship between age and the manifestations of and mortality associated with severe malaria. Dondorp, Arjen M. Lee, Sue J Faiz, Md Abul Mishra, Saroj K Price, Ric N Tjitra, Emiliana Than, Marlar Mohammad Iqbal, Omar@Ye Htut, Assoc. Prof. Dr. Mohanty, Sanjib Emran, Yunus Ridwanur, Rahman Nosten, Francois Anstey, Nicholas M. Day, Nicholas P. J. White, Nicholas J. sue@tropmedres.ac iqbalomar@unimap.edu.my Severe malaria Adult Age distribution Anemia Asia Mortality Link to publisher's homepage at http://cid.oxfordjournals.org/ Background. The reported case-fatality rate associated with severe malaria varies widely. Whether age is an independent risk factor is uncertain. Methods. In a large, multicenter treatment trial conducted in Asia, the presenting manifestations and outcome of severe malaria were analyzed in relation to age. Results. Among 1050 patients with severe malaria, the mortality increased stepwise, from 6.1% in children (age, <10 years) to 36.5% in patients aged >50 years (P < .001). Compared with adults aged 21-50 years, the decreased risk of death among children (adjusted odds ratio, 0.06; 95% confidence interval, 0.01-0.23; P < .001) and the increased risk of death among patients aged >50 years (adjusted odds ratio, 1.88; 95% confidence interval, 1.01-3.52; P = .046) was independent of the variation in presenting manifestations. The incidence of anemia and convulsions decreased with age, whereas the incidence of hyperparasitemia, jaundice, and renal insufficiency increased with age. Coma and metabolic acidosis did not vary with age and were the strongest predictors of a fatal outcome. The number of severity signs at hospital admission also had a strong prognostic value. Conclusion. Presenting syndromes in severe malaria depend on age, although the incidence and the strong prognostic significance of coma and acidosis are similar at all ages. Age is an independent risk factor for a fatal outcome of the disease. 2014-04-10T02:35:06Z 2014-04-10T02:35:06Z 2008 Article Clinical Infectious Diseases, vol. 47(2), 2008, pages 151-157 1058-4838 (Print) 1537-6591 (Online) http://dspace.unimap.edu.my:80/dspace/handle/123456789/33578 http://cid.oxfordjournals.org/content/47/2/151.long 10.1086/589287 en Oxford University Press |
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Malaysia |
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Universiti Malaysia Perlis |
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http://dspace.unimap.edu.my/ |
| language |
English |
| topic |
Severe malaria Adult Age distribution Anemia Asia Mortality |
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Severe malaria Adult Age distribution Anemia Asia Mortality Dondorp, Arjen M. Lee, Sue J Faiz, Md Abul Mishra, Saroj K Price, Ric N Tjitra, Emiliana Than, Marlar Mohammad Iqbal, Omar@Ye Htut, Assoc. Prof. Dr. Mohanty, Sanjib Emran, Yunus Ridwanur, Rahman Nosten, Francois Anstey, Nicholas M. Day, Nicholas P. J. White, Nicholas J. The relationship between age and the manifestations of and mortality associated with severe malaria. |
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Link to publisher's homepage at http://cid.oxfordjournals.org/ |
| author2 |
sue@tropmedres.ac |
| author_facet |
sue@tropmedres.ac Dondorp, Arjen M. Lee, Sue J Faiz, Md Abul Mishra, Saroj K Price, Ric N Tjitra, Emiliana Than, Marlar Mohammad Iqbal, Omar@Ye Htut, Assoc. Prof. Dr. Mohanty, Sanjib Emran, Yunus Ridwanur, Rahman Nosten, Francois Anstey, Nicholas M. Day, Nicholas P. J. White, Nicholas J. |
| format |
Article |
| author |
Dondorp, Arjen M. Lee, Sue J Faiz, Md Abul Mishra, Saroj K Price, Ric N Tjitra, Emiliana Than, Marlar Mohammad Iqbal, Omar@Ye Htut, Assoc. Prof. Dr. Mohanty, Sanjib Emran, Yunus Ridwanur, Rahman Nosten, Francois Anstey, Nicholas M. Day, Nicholas P. J. White, Nicholas J. |
| author_sort |
Dondorp, Arjen M. |
| title |
The relationship between age and the manifestations of and mortality associated with severe malaria. |
| title_short |
The relationship between age and the manifestations of and mortality associated with severe malaria. |
| title_full |
The relationship between age and the manifestations of and mortality associated with severe malaria. |
| title_fullStr |
The relationship between age and the manifestations of and mortality associated with severe malaria. |
| title_full_unstemmed |
The relationship between age and the manifestations of and mortality associated with severe malaria. |
| title_sort |
relationship between age and the manifestations of and mortality associated with severe malaria. |
| publisher |
Oxford University Press |
| publishDate |
2014 |
| url |
http://dspace.unimap.edu.my:80/dspace/handle/123456789/33578 |
| _version_ |
1643797217737179136 |