Prolonging glucose sensor's performance in In Vivo environment
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Faculty of Computer Science & Information Technology, University of Malaya
2014
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my.unimap-348182014-05-28T04:37:42Z Prolonging glucose sensor's performance in In Vivo environment Nashrul Fazli, Mohd Nasir, Dr. Yang Ying nashrul@unimap.edu.my Biosensor Glucose sensor Immobilization technique Sol gel technique Biocompatibility Link to publisher's homepage at http://ejum.fsktm.um.edu.my/ In this paper, a sol gel based needle type biosensor using 3-glycidoxypropyl dimethylethoxy silane, as silane agent was developed to improve the immobilization efficiency of glucose oxidase (GOD). The glucose sensor was coated with 3C-copolymer as the outmost layer to increase sensor’s biocompatibility. The biosensor’s performance fabricated by this technique was compared with the conventional sensors which use glutaraldehyde as the cross link agent for immobilization of GOD. Both types of sensor were immersed in 20 mM glucose solution for more than 24 hours and the sol gel based sensor exhibited better stability. This indicates that the sol gel immobilization technique applied is able to retain enzyme for longer time of period compared to the conventional method. Furthermore, the study revealed once the sensors were tested in a glucose solution containing 1% bovine serum albumin in a long term stability test, the performance of the sol gel based sensor coated with 3C-copolymer was not affected considerably by protein adsorption, which was a vital character for an in vivo biosensor. 2014-05-28T04:37:42Z 2014-05-28T04:37:42Z 2006 Article Engineering e-Transaction, vol. 1(2), 2006, pages 1-4 1823-6379 http://ejum.fsktm.um.edu.my/ArticleInformation.aspx?ArticleID=399 http://dspace.unimap.edu.my:80/dspace/handle/123456789/34818 en Faculty of Computer Science & Information Technology, University of Malaya |
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English |
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Biosensor Glucose sensor Immobilization technique Sol gel technique Biocompatibility |
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Biosensor Glucose sensor Immobilization technique Sol gel technique Biocompatibility Nashrul Fazli, Mohd Nasir, Dr. Yang Ying Prolonging glucose sensor's performance in In Vivo environment |
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Link to publisher's homepage at http://ejum.fsktm.um.edu.my/ |
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nashrul@unimap.edu.my |
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nashrul@unimap.edu.my Nashrul Fazli, Mohd Nasir, Dr. Yang Ying |
| format |
Article |
| author |
Nashrul Fazli, Mohd Nasir, Dr. Yang Ying |
| author_sort |
Nashrul Fazli, Mohd Nasir, Dr. |
| title |
Prolonging glucose sensor's performance in In Vivo environment |
| title_short |
Prolonging glucose sensor's performance in In Vivo environment |
| title_full |
Prolonging glucose sensor's performance in In Vivo environment |
| title_fullStr |
Prolonging glucose sensor's performance in In Vivo environment |
| title_full_unstemmed |
Prolonging glucose sensor's performance in In Vivo environment |
| title_sort |
prolonging glucose sensor's performance in in vivo environment |
| publisher |
Faculty of Computer Science & Information Technology, University of Malaya |
| publishDate |
2014 |
| url |
http://dspace.unimap.edu.my:80/dspace/handle/123456789/34818 |
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1643797607976271872 |