Computational design, synthesis and evaluation of caffeine imprinted molecular imprint polymer (MIP)

Computational design, synthesis and evaluation of caffeine imprinted molecular imprint polymer (MIP)

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Bibliographic Details
Main Author: Wan Mohd Akmal, Wan Long
Other Authors: Dr. A.K.M. Shafiqul Islam
Format: Learning Object
Language:English
Published: Universiti Malaysia Perlis (UniMAP) 2015
Subjects:
Caffeine
Molecular imprinting polymer (MIP)
Caffeinated product
Coffee
Online Access:http://dspace.unimap.edu.my:80/xmlui/handle/123456789/38450
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Institution: Universiti Malaysia Perlis
Language: English
id my.unimap-38450
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spelling my.unimap-384502015-01-08T09:18:01Z Computational design, synthesis and evaluation of caffeine imprinted molecular imprint polymer (MIP) Wan Mohd Akmal, Wan Long Dr. A.K.M. Shafiqul Islam Caffeine Molecular imprinting polymer (MIP) Caffeinated product Coffee Access is limited to UniMAP community. Caffeine had been extensively studied in various fields due to its beneficial effect on human and in the same time it still has negative effects. Therefore, a suitable method is needed to isolate caffeine. In this research, molecular imprint polymer (MIP) was used to study the rebinding properties of caffeine in order to isolate from coffee. MIP possessed host-guest concept with highly specific recognition site using molecular template. A rational approach was taken to enhance the performance of MIP of caffeine by involving computational design, synthesis of MIP and evaluation through rebinding assay of caffeine. The experiment is started with computational design to simulate the polymer properties through molecular modelling using HyperChem 6.0 software. This molecular modelling is applied with AM1 (Austin Method 1) of semi empirical method with Polak-Ribiere algorithm to determine the suitable functional monomer and cross linker for MIP preparations. The ratio of 1:4, 1:4.5 and 1:5 for caffeine and itaconic acid as template and functional monomer respectively were expected to have a good binding properties in MIP synthesis. The caffeine was removed from MIP using Soxhlet extraction and left the cavities inside the MIP. Rebinding assay of caffeine inside the MIP was studied using spectroscopy. The result show that ratio 4 having high binding selectivity of caffeine which is 83 %. 2015-01-08T09:18:01Z 2015-01-08T09:18:01Z 2013-05 Learning Object http://dspace.unimap.edu.my:80/xmlui/handle/123456789/38450 en Universiti Malaysia Perlis (UniMAP) School of Bioprocess Engineering
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Caffeine
Molecular imprinting polymer (MIP)
Caffeinated product
Coffee
spellingShingle Caffeine
Molecular imprinting polymer (MIP)
Caffeinated product
Coffee
Wan Mohd Akmal, Wan Long
Computational design, synthesis and evaluation of caffeine imprinted molecular imprint polymer (MIP)
description Access is limited to UniMAP community.
author2 Dr. A.K.M. Shafiqul Islam
author_facet Dr. A.K.M. Shafiqul Islam
Wan Mohd Akmal, Wan Long
format Learning Object
author Wan Mohd Akmal, Wan Long
author_sort Wan Mohd Akmal, Wan Long
title Computational design, synthesis and evaluation of caffeine imprinted molecular imprint polymer (MIP)
title_short Computational design, synthesis and evaluation of caffeine imprinted molecular imprint polymer (MIP)
title_full Computational design, synthesis and evaluation of caffeine imprinted molecular imprint polymer (MIP)
title_fullStr Computational design, synthesis and evaluation of caffeine imprinted molecular imprint polymer (MIP)
title_full_unstemmed Computational design, synthesis and evaluation of caffeine imprinted molecular imprint polymer (MIP)
title_sort computational design, synthesis and evaluation of caffeine imprinted molecular imprint polymer (mip)
publisher Universiti Malaysia Perlis (UniMAP)
publishDate 2015
url http://dspace.unimap.edu.my:80/xmlui/handle/123456789/38450
_version_ 1643798766027800576

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