Analysis of MDA-MB-231 cancer cell Dielectrophoretic response
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Universiti Malaysia Perlis (UniMAP)
2021
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my.unimap-695842021-02-08T04:07:54Z Analysis of MDA-MB-231 cancer cell Dielectrophoretic response Mohd Anuar, Md Ali Aminuddin, Ahmad Kayani Burhanuddin, Yeop Majlis burhan@ukm.edu.my Dielectrophoresis Dielectrophoretic force Cancer cells MDA-MB-231 Link to publisher's homepage at http://ijneam.unimap.edu.my Dielectrophoresis (DEP) is a phenomenon where a neutral particle can be either attracted to (pDEP) or repelled away from (nDEP) specific regions with highest electric field gradient. In previous work, we demonstrated the simulation and experimental work with yeast cell suspended in deionized water, where the result showed that yeast cells experience linear and rotational motion under DEP. In this work, we extend our work into the study of cancer cells, specifically MDA-MB-231 cell. While no DEP response is predicted at higher DMEM concentration, for MDA-MB-231 cells suspended in diluted DMEM (1%), the simulation shows that within frequency range of 1 kHz to 10 GHz, the cross-over frequency located at 80 kHz and 120 MHz, with cell demonstrates pDEP at frequency range between those two, while nDEP is at both frequency ranges less than 80 kHz and higher than 120 MHz. The following experimental work justify the simulation result, with the cell exhibits nDEP at 50 kHz, while pDEP is observed at 100, 200 and 500 kHz, among those selected frequencies. Due to substantial difference between the cell mass, the response time is hugely different with cancer cell shown significant reduction, however, the quantification is expected at future work. 2021-02-08T04:07:54Z 2021-02-08T04:07:54Z 2020-12 Article International Journal of Nanoelectronics and Materials, vol.13(Special Issue), 2020, pages 243-248 1985-5761 (Printed) 1997-4434 (Online) http://dspace.unimap.edu.my:80/xmlui/handle/123456789/69584 en NANOSYM, 2019; Universiti Malaysia Perlis (UniMAP) |
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| topic |
Dielectrophoresis Dielectrophoretic force Cancer cells MDA-MB-231 |
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Dielectrophoresis Dielectrophoretic force Cancer cells MDA-MB-231 Mohd Anuar, Md Ali Aminuddin, Ahmad Kayani Burhanuddin, Yeop Majlis Analysis of MDA-MB-231 cancer cell Dielectrophoretic response |
| description |
Link to publisher's homepage at http://ijneam.unimap.edu.my |
| author2 |
burhan@ukm.edu.my |
| author_facet |
burhan@ukm.edu.my Mohd Anuar, Md Ali Aminuddin, Ahmad Kayani Burhanuddin, Yeop Majlis |
| format |
Article |
| author |
Mohd Anuar, Md Ali Aminuddin, Ahmad Kayani Burhanuddin, Yeop Majlis |
| author_sort |
Mohd Anuar, Md Ali |
| title |
Analysis of MDA-MB-231 cancer cell Dielectrophoretic response |
| title_short |
Analysis of MDA-MB-231 cancer cell Dielectrophoretic response |
| title_full |
Analysis of MDA-MB-231 cancer cell Dielectrophoretic response |
| title_fullStr |
Analysis of MDA-MB-231 cancer cell Dielectrophoretic response |
| title_full_unstemmed |
Analysis of MDA-MB-231 cancer cell Dielectrophoretic response |
| title_sort |
analysis of mda-mb-231 cancer cell dielectrophoretic response |
| publisher |
Universiti Malaysia Perlis (UniMAP) |
| publishDate |
2021 |
| url |
http://dspace.unimap.edu.my:80/xmlui/handle/123456789/69584 |
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1698698625913192448 |