Computational modeling of Caspase activated DNAase (CAD) regulation towards Apoptosis
Organized by School of Mechatronic Engineering (UniMAP) & co-organized by The Institution of Engineering Malaysia (IEM), 11th - 13th October 2009 at Batu Feringhi, Penang, Malaysia.
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Universiti Malaysia Perlis
2009
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| Online Access: | http://dspace.unimap.edu.my/xmlui/handle/123456789/7267 |
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my.unimap-72672009-11-17T03:43:47Z Computational modeling of Caspase activated DNAase (CAD) regulation towards Apoptosis Mohd Yusof, Baharuddin Caspase activated deoxyribonuclease (CAD) ICAD DNA fragmentation Apoptosis Caspase-3 Organized by School of Mechatronic Engineering (UniMAP) & co-organized by The Institution of Engineering Malaysia (IEM), 11th - 13th October 2009 at Batu Feringhi, Penang, Malaysia. Caspase activated deoxyribonuclease (CAD) is the protein that transmit nuclear localization signal which will induced DNA fragmentation. Both CAD and its inhibitor ICAD is the key for apoptosis. As CAD is binding on RNA, ICAD-L will bind to its budding chain improving the folding. Once CAD synthesis is done, ICAD-L will still bind with CAD forming DFF which is the CAD: ICAD complex. On the contrary, ICAD-S couldn’t bind with CAD budding chain, therefore do not form DFF. When Caspase-3 is activated downstream in Caspase-3 Cascade, ICAD-L will cleaved and release active CAD to degrade DNA. 2009-11-13T01:54:47Z 2009-11-13T01:54:47Z 2009-10-11 Working Paper p.1A7 1 - 1A7 4 http://hdl.handle.net/123456789/7267 en Proceedings of the International Conference on Man-Machine Systems (ICoMMS 2009) Universiti Malaysia Perlis |
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Malaysia |
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| language |
English |
| topic |
Caspase activated deoxyribonuclease (CAD) ICAD DNA fragmentation Apoptosis Caspase-3 |
| spellingShingle |
Caspase activated deoxyribonuclease (CAD) ICAD DNA fragmentation Apoptosis Caspase-3 Mohd Yusof, Baharuddin Computational modeling of Caspase activated DNAase (CAD) regulation towards Apoptosis |
| description |
Organized by School of Mechatronic Engineering (UniMAP) & co-organized by The Institution of Engineering Malaysia (IEM), 11th - 13th October 2009 at Batu Feringhi, Penang, Malaysia. |
| format |
Working Paper |
| author |
Mohd Yusof, Baharuddin |
| author_facet |
Mohd Yusof, Baharuddin |
| author_sort |
Mohd Yusof, Baharuddin |
| title |
Computational modeling of Caspase activated DNAase (CAD) regulation towards Apoptosis |
| title_short |
Computational modeling of Caspase activated DNAase (CAD) regulation towards Apoptosis |
| title_full |
Computational modeling of Caspase activated DNAase (CAD) regulation towards Apoptosis |
| title_fullStr |
Computational modeling of Caspase activated DNAase (CAD) regulation towards Apoptosis |
| title_full_unstemmed |
Computational modeling of Caspase activated DNAase (CAD) regulation towards Apoptosis |
| title_sort |
computational modeling of caspase activated dnaase (cad) regulation towards apoptosis |
| publisher |
Universiti Malaysia Perlis |
| publishDate |
2009 |
| url |
http://dspace.unimap.edu.my/xmlui/handle/123456789/7267 |
| _version_ |
1643788743056818176 |