The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles

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Main Author:	Azman, Muhamad @ Muhamad Nor
Other Authors:	School of Bioprocess Engineering
Format:	Other
Language:	English
Published:	Universiti Malaysia Perlis (UniMAP) 2022
Subjects:	Nanoparticles (NPs) Biodegradable polymeric nanoparticles (NPs) Polymers
Online Access:	http://dspace.unimap.edu.my:80/xmlui/handle/123456789/73355
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Institution:	Universiti Malaysia Perlis
Language:	English

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spelling	my.unimap-733552022-01-13T04:08:21Z The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles Azman, Muhamad @ Muhamad Nor School of Bioprocess Engineering Nanoparticles (NPs) Biodegradable polymeric nanoparticles (NPs) Polymers Access is limited to UniMAP community. Biodegradable polymeric nanoparticles (NPs) are produced via nanoprecipitation method also known as solvent displacement method that involved chemical reaction of organic phase to aqueous phase. The objectives of this study are to study the optimum condition of some parameters for the biodegradable polymeric nanoparticles (NPs) production by using design of experiment (DOE) approach. The recommended optimized condition that was suggested by DOE approached were; volume ratio of organic phase to aqueous phase at 10, agitation speed on aqueous phase at 1000 rpm and polymer concentration at 1 mg/mL. Under this operating condition, the model was predicted to achieve lower particle size in polymeric NPs which is at 398.126 nm. Then, the suggested optimum process parameters were applied for stabilization with the addition of polyvinylpyrrolidone (PVP) in the aqueous phase. Observation based on their color change was done for one month. The surfactant ratio was fixed at 1 wt%. The effectiveness and physico-chemical properties of functional particles in production of biodegradable polymeric NPs were investigated by using Scanning Electron Microscopic (SEM) and Fourier Transform Infrared (FTIR). 2022-01-13T04:08:21Z 2022-01-13T04:08:21Z 2017-06 Other http://dspace.unimap.edu.my:80/xmlui/handle/123456789/73355 en Universiti Malaysia Perlis (UniMAP)
institution	Universiti Malaysia Perlis
building	UniMAP Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Perlis
content_source	UniMAP Library Digital Repository
url_provider	http://dspace.unimap.edu.my/
language	English
topic	Nanoparticles (NPs) Biodegradable polymeric nanoparticles (NPs) Polymers
spellingShingle	Nanoparticles (NPs) Biodegradable polymeric nanoparticles (NPs) Polymers Azman, Muhamad @ Muhamad Nor The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles
description	Access is limited to UniMAP community.
author2	School of Bioprocess Engineering
author_facet	School of Bioprocess Engineering Azman, Muhamad @ Muhamad Nor
format	Other
author	Azman, Muhamad @ Muhamad Nor
author_sort	Azman, Muhamad @ Muhamad Nor
title	The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles
title_short	The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles
title_full	The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles
title_fullStr	The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles
title_full_unstemmed	The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles
title_sort	effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles
publisher	Universiti Malaysia Perlis (UniMAP)
publishDate	2022
url	http://dspace.unimap.edu.my:80/xmlui/handle/123456789/73355
_version_	1724610033651548160

The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles

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