Nanogap Dielectric Biosensor for label free DNA Hybridization detection
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Universiti Malaysia Perlis
2010
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my.unimap-74462010-01-01T04:07:08Z Nanogap Dielectric Biosensor for label free DNA Hybridization detection Uda, Hashim Muhamad Emi Azri, Shohini Harbant, Singh uda@unimap.edu.my Nanogap DNA hybridization Lab-on-a-chip Spacer Patterning technology Reverse Spacer Lithographic Sensors Deoxyribonucleic acid (DNA) Link to publisher's homepage at http://www.unimap.edu.my/ Sensors based on nanogap capacitance changes are being developed for genomic and proteomic applications because they offer label-free detection on platforms amenable to high throughput configurations. This paper presents the development of fabrication and characterisation of lab-on-a-chip methodology for deoxyribonucleic acid (DNA) hybridization detection. The electrodes made of amorphous silicon (a-Si) separated by a narrow gap whose width is comparable to the size of a DNA molecule are used as a trap. During hybridization, trapped DNA change from single stranded DNA (ssDNA) to double stranded DNA (dsDNA) cause the change of charge density of molecules structure. This change results in an effective change of capacitance that can be monitored electronically by using dielectric spectroscopy, a type of impedance spectroscopy that measures the dielectric properties of a medium as a function of frequency. 2010-01-01T04:07:08Z 2010-01-01T04:07:08Z 2007 Article Journal of Engineering Research and Education, vol. 4, 2007, pages 41-49. 1823-2981 http://www.unimap.edu.my/ http://hdl.handle.net/123456789/7446 en Universiti Malaysia Perlis |
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English |
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Nanogap DNA hybridization Lab-on-a-chip Spacer Patterning technology Reverse Spacer Lithographic Sensors Deoxyribonucleic acid (DNA) |
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Nanogap DNA hybridization Lab-on-a-chip Spacer Patterning technology Reverse Spacer Lithographic Sensors Deoxyribonucleic acid (DNA) Uda, Hashim Muhamad Emi Azri, Shohini Harbant, Singh Nanogap Dielectric Biosensor for label free DNA Hybridization detection |
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Link to publisher's homepage at http://www.unimap.edu.my/ |
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uda@unimap.edu.my |
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uda@unimap.edu.my Uda, Hashim Muhamad Emi Azri, Shohini Harbant, Singh |
| format |
Article |
| author |
Uda, Hashim Muhamad Emi Azri, Shohini Harbant, Singh |
| author_sort |
Uda, Hashim |
| title |
Nanogap Dielectric Biosensor for label free DNA Hybridization detection |
| title_short |
Nanogap Dielectric Biosensor for label free DNA Hybridization detection |
| title_full |
Nanogap Dielectric Biosensor for label free DNA Hybridization detection |
| title_fullStr |
Nanogap Dielectric Biosensor for label free DNA Hybridization detection |
| title_full_unstemmed |
Nanogap Dielectric Biosensor for label free DNA Hybridization detection |
| title_sort |
nanogap dielectric biosensor for label free dna hybridization detection |
| publisher |
Universiti Malaysia Perlis |
| publishDate |
2010 |
| url |
http://dspace.unimap.edu.my/xmlui/handle/123456789/7446 |
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1643788828728623104 |