Intelligent design of microneedle structure for drug delivery system

Master of Science in Microeletronic Engineering

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Bibliographic Details
Main Author:	Nur Afifah, Ismail
Other Authors:	Nurul Izza, Mohd Nor, Dr.
Format:	Thesis
Language:	English
Published:	Universiti Malaysia Perlis (UniMAP) 2015
Subjects:	Transdermal medication Drug delivery systems Microneedle Microneedle > Design and construction Transdermal drug delivery (TDD)
Online Access:	http://dspace.unimap.edu.my:80/xmlui/handle/123456789/77063
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Institution:	Universiti Malaysia Perlis
Language:	English

id	my.unimap-77063
record_format	dspace
spelling	my.unimap-770632022-11-17T04:24:52Z Intelligent design of microneedle structure for drug delivery system Nur Afifah, Ismail Nurul Izza, Mohd Nor, Dr. Transdermal medication Drug delivery systems Microneedle Microneedle -- Design and construction Transdermal drug delivery (TDD) Master of Science in Microeletronic Engineering Transdermal drug delivery (TDD) is an attractive system to transport drugs or biological compounds into human body, for its apparent benefit of eliminating pain and inconvenient intravenous injections. Microneedle is one example of TDD devices that involves various parameters and complex set of design requirements. Design and analysis of microneedle structure for drug delivery system has been an important issue among researchers especially in biological micro-electro-mechanical system (BioMEMS) field. As MEMS-based microneedles develop in complexity, there is a greater need to reduce the time taken for a MEMS designer to analyze their design before proceed to fabrication process. This study proposed the used of artificial intelligence (AI) methods as a systematic optimization tool to reduce the amount of time taken for designing a microneedle structure. An optimization of microneedle structure is demonstrated by using two techniques of AI which are particle swarm optimization (PSO) and genetic algorithm (GA). A hybrid optimization algorithm has been investigated by combining the PSO with GA to improve computation competency. This combination method is called hybrid PSO-GA (HPSOGA). There are eight design variables of microneedle structure to be optimized in this research. The complex design of microneedle structure considers the shape of microneedle, material used, size of the array, the base of microneedle, the lumen base, the height of microneedle, the height of the lumen, and the height of the drug container or reservoir. 2015 2022-11-17T04:22:40Z 2022-11-17T04:22:40Z Thesis http://dspace.unimap.edu.my:80/xmlui/handle/123456789/77063 en Universiti Malaysia Perlis (UniMAP) Universiti Malaysia Perlis (UniMAP) School of Microelectronic Engineering
institution	Universiti Malaysia Perlis
building	UniMAP Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Perlis
content_source	UniMAP Library Digital Repository
url_provider	http://dspace.unimap.edu.my/
language	English
topic	Transdermal medication Drug delivery systems Microneedle Microneedle -- Design and construction Transdermal drug delivery (TDD)
spellingShingle	Transdermal medication Drug delivery systems Microneedle Microneedle -- Design and construction Transdermal drug delivery (TDD) Nur Afifah, Ismail Intelligent design of microneedle structure for drug delivery system
description	Master of Science in Microeletronic Engineering
author2	Nurul Izza, Mohd Nor, Dr.
author_facet	Nurul Izza, Mohd Nor, Dr. Nur Afifah, Ismail
format	Thesis
author	Nur Afifah, Ismail
author_sort	Nur Afifah, Ismail
title	Intelligent design of microneedle structure for drug delivery system
title_short	Intelligent design of microneedle structure for drug delivery system
title_full	Intelligent design of microneedle structure for drug delivery system
title_fullStr	Intelligent design of microneedle structure for drug delivery system
title_full_unstemmed	Intelligent design of microneedle structure for drug delivery system
title_sort	intelligent design of microneedle structure for drug delivery system
publisher	Universiti Malaysia Perlis (UniMAP)
publishDate	2015
url	http://dspace.unimap.edu.my:80/xmlui/handle/123456789/77063
_version_	1751537838738898944

Intelligent design of microneedle structure for drug delivery system

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