Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst
MUCEET 2009 is organized by Malaysian Technical Universities Network (MTUN) comprising of Universiti Malaysia Perlis (UniMAP), Universiti Tun Hussein Onn (UTHM), Universiti Teknikal Melaka (UTeM) and Universiti Malaysia Pahang (UMP), 20th - 22nd June 2009 at M. S. Garden Hotel, Kuantan, Pahang.
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Universiti Malaysia Pahang (UMP)
2010
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my.unimap-86702010-08-13T09:17:30Z Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst Wu, lihua Zhou, zhongqiang Kong, Yong Liew Amino amide hydrochlorides Cinchonine Sulfonamide Asymmetric transfer hydrogenation (ATH) Malaysian Technical Universities Conference on Engineering and Technology (MUCEET) MUCEET 2009 is organized by Malaysian Technical Universities Network (MTUN) comprising of Universiti Malaysia Perlis (UniMAP), Universiti Tun Hussein Onn (UTHM), Universiti Teknikal Melaka (UTeM) and Universiti Malaysia Pahang (UMP), 20th - 22nd June 2009 at M. S. Garden Hotel, Kuantan, Pahang. Chiral amide ligands were synthesized from L-proline and cinchonine and their application to asymmetric transfer hydrogenation of prochiral ketones was studied. Transfer hydrogen reaction catalyzed by proline based amino amide hydrochlorides was carried out in aqueous HCOONa while sulfonamide derived from cinchonin was carried out in iso-propanol containing NaOH using [RuCl2(p-cymene)] 2 as catalyst. The ATH of Chiral amino amide hydrochlorides reaction yielded excellent conversion rates of > 99% with good enantioselectivities (up to 76.9% ee) with water as solvent. The reaction of the substituted acetophenone showed that the enantioselectivity was not significantly affected by the type of substituent on aryl but also by alkyl. 2010-08-13T09:17:30Z 2010-08-13T09:17:30Z 2009-06-20 Working Paper http://hdl.handle.net/123456789/8670 en Proceedings of the Malaysian Technical Universities Conference on Engineering and Technology (MUCEET) 2009 Universiti Malaysia Pahang (UMP) |
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Amino amide hydrochlorides Cinchonine Sulfonamide Asymmetric transfer hydrogenation (ATH) Malaysian Technical Universities Conference on Engineering and Technology (MUCEET) |
| spellingShingle |
Amino amide hydrochlorides Cinchonine Sulfonamide Asymmetric transfer hydrogenation (ATH) Malaysian Technical Universities Conference on Engineering and Technology (MUCEET) Wu, lihua Zhou, zhongqiang Kong, Yong Liew Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst |
| description |
MUCEET 2009 is organized by Malaysian Technical Universities Network (MTUN) comprising of Universiti Malaysia Perlis (UniMAP), Universiti Tun Hussein Onn (UTHM), Universiti Teknikal Melaka (UTeM) and Universiti Malaysia Pahang (UMP), 20th - 22nd June 2009 at M. S. Garden Hotel, Kuantan, Pahang. |
| format |
Working Paper |
| author |
Wu, lihua Zhou, zhongqiang Kong, Yong Liew |
| author_facet |
Wu, lihua Zhou, zhongqiang Kong, Yong Liew |
| author_sort |
Wu, lihua |
| title |
Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst |
| title_short |
Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst |
| title_full |
Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst |
| title_fullStr |
Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst |
| title_full_unstemmed |
Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst |
| title_sort |
amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst |
| publisher |
Universiti Malaysia Pahang (UMP) |
| publishDate |
2010 |
| url |
http://dspace.unimap.edu.my/xmlui/handle/123456789/8670 |
| _version_ |
1643789295178219520 |