Synthesis of aspirin-chalcone derivatives and their antibacterial activity
Aspirin and chalcone have long been used for its medicinal purpose due to its biological activity. This research focused on the synthesis of aspirin-chalcone derivatives resulting from the reactions of chalcone intermediate with acetylsalicyloyl chloride. Aspirinchalcone derivatives have been syn...
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| Main Author: | |
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| Format: | Final Year Project Report |
| Language: | English English |
| Published: |
Universiti Malaysia Sarawak, (UNIMAS)
2015
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/10833/1/Ji.pdf http://ir.unimas.my/id/eprint/10833/4/Lim%20Ji%20ft.pdf http://ir.unimas.my/id/eprint/10833/ |
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| Institution: | Universiti Malaysia Sarawak |
| Language: | English English |
| Summary: | Aspirin and chalcone have long been used for its medicinal purpose due to its biological
activity. This research focused on the synthesis of aspirin-chalcone derivatives resulting
from the reactions of chalcone intermediate with acetylsalicyloyl chloride. Aspirinchalcone
derivatives have been synthesized. The successfully synthesized compounds were
characterized using FTIR, 1H NMR and 13C NMR. Antibacterial assay was carried out
using disc diffusion method against the growth of Escherichia coli ATCC 29522. However,
the result indicated that the newly synthesized aspirin-chalcone derivatives showed no
antibacterial activity against E.coli. |
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