Synthesis, characterization and antibacterial activity of bis thiourea derivatives
A series of bisthiourea derivatives were succesfully synthesized by reaction of benzene-1, 4 dicarbonyl isothiocyanate intermediates and isophthaloyl dichloride, with a series of aromatic amine at ortho, meta and para position. The structure of synthesised compound characterized by infra-red spect...
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| Main Author: | |
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| Format: | Final Year Project Report |
| Language: | English |
| Published: |
Universiti Malaysia Sarawak, (UNIMAS)
2015
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| Online Access: | http://ir.unimas.my/id/eprint/11053/9/Synthesis%2C%20Characterization..%28fulltext%29.pdf http://ir.unimas.my/id/eprint/11053/ |
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| Institution: | Universiti Malaysia Sarawak |
| Language: | English |
| Summary: | A series of bisthiourea derivatives were succesfully synthesized by reaction of benzene-1, 4 dicarbonyl isothiocyanate intermediates and isophthaloyl dichloride, with a series of aromatic amine at ortho, meta and para position. The structure of synthesised compound characterized by infra-red spectroscopy (FTIR), 1H Nuclear magnetic resonances, and 13C Nuclear magnetic resonances. The synthesised compounds were screened for their antibacterial properties using Gram-negative bacteria Escherichia coli (E.coli) by using disc diffusion method. All of synthesized series showed negative results towards antibacterial activity. |
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