Wnt-4 regulation by the Wilms' tumour suppressor gene, WT1

• Main Authors: Sim, Edmund U. H., Smith, Aaron, Szilagi, Elida, Rae, Fiona, H Little, Melissa, Ioannou, Panos, Lindsay, Megan H
• Format: E-Article
• Language: English
• Published: Nature Publishing Group 2002
• Subjects: R Medicine (General)
• Online Access: http://ir.unimas.my/id/eprint/16919/1/Wnt-4%20regulation%20by%20the%20Wilms%27%20tumour%20%28abstract%29.pdf; http://ir.unimas.my/id/eprint/16919/; https://www.nature.com/onc/
• Institution: Universiti Malaysia Sarawak

The Wilms' tumour suppressor gene, WT1, encodes multiple nuclear protein isoforms, all containing four C-terminal zinc finger motifs. WT1 proteins can both activate and repress putative target genes in vitro, although the in vivo relevance of these putative target genes is often unverified. WT1...