Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death

Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death

In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponin I and T (cTn-T & T), and lactate dehydrogenase] measured by immunoassay technique, in the pos...

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Main Authors: Octavio, Carvajal-Zarrabal, Patricia M., Hayward-Jones, Cirilo Nolasco, Nolasco-Hipólito, Dulce, Barradas-Dermitz, Ana Laura, Calderón-Garcidueñas, Noe, Lopez-Amador
Format: E-Article
Published: Blackwell Publishing Inc. 2017
Subjects:
TP Chemical technology
Online Access:http://ir.unimas.my/id/eprint/17878/
http://onlinelibrary.wiley.com/doi/10.1111/1556-4029.13397/full
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Institution: Universiti Malaysia Sarawak
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spelling my.unimas.ir.178782017-10-02T07:05:32Z http://ir.unimas.my/id/eprint/17878/ Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death Octavio, Carvajal-Zarrabal Patricia M., Hayward-Jones Cirilo Nolasco, Nolasco-Hipólito Dulce, Barradas-Dermitz Ana Laura, Calderón-Garcidueñas Noe, Lopez-Amador TP Chemical technology In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponin I and T (cTn-T & T), and lactate dehydrogenase] measured by immunoassay technique, in the postmortem diagnosis of SCD. Two groups were compared, 20 corpses with SCD and 8 controls. Statistical significance was determined by variance analysis procedures, with a post hoc Tukey multiple range test for comparison of means (P <0.05). SCD cases showed significantly higher levels (P <0.05) of cTn-T and cTn-I compared to the control group. Although only cases within the first 8 hours of postmortem interval were included, and the control group consisted mainly of violent death cases, our results suggest that blood troponin levels may be useful to support a diagnosis of SCD. Blackwell Publishing Inc. 2017 E-Article PeerReviewed Octavio, Carvajal-Zarrabal and Patricia M., Hayward-Jones and Cirilo Nolasco, Nolasco-Hipólito and Dulce, Barradas-Dermitz and Ana Laura, Calderón-Garcidueñas and Noe, Lopez-Amador (2017) Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death. Journal of Forensic Sciences, 62 (5). pp. 1332-1335. ISSN 0022-1198 http://onlinelibrary.wiley.com/doi/10.1111/1556-4029.13397/full DOI: 10.1111/1556-4029.13397
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Octavio, Carvajal-Zarrabal
Patricia M., Hayward-Jones
Cirilo Nolasco, Nolasco-Hipólito
Dulce, Barradas-Dermitz
Ana Laura, Calderón-Garcidueñas
Noe, Lopez-Amador
Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death
description In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponin I and T (cTn-T & T), and lactate dehydrogenase] measured by immunoassay technique, in the postmortem diagnosis of SCD. Two groups were compared, 20 corpses with SCD and 8 controls. Statistical significance was determined by variance analysis procedures, with a post hoc Tukey multiple range test for comparison of means (P <0.05). SCD cases showed significantly higher levels (P <0.05) of cTn-T and cTn-I compared to the control group. Although only cases within the first 8 hours of postmortem interval were included, and the control group consisted mainly of violent death cases, our results suggest that blood troponin levels may be useful to support a diagnosis of SCD.
format E-Article
author Octavio, Carvajal-Zarrabal
Patricia M., Hayward-Jones
Cirilo Nolasco, Nolasco-Hipólito
Dulce, Barradas-Dermitz
Ana Laura, Calderón-Garcidueñas
Noe, Lopez-Amador
author_facet Octavio, Carvajal-Zarrabal
Patricia M., Hayward-Jones
Cirilo Nolasco, Nolasco-Hipólito
Dulce, Barradas-Dermitz
Ana Laura, Calderón-Garcidueñas
Noe, Lopez-Amador
author_sort Octavio, Carvajal-Zarrabal
title Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death
title_short Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death
title_full Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death
title_fullStr Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death
title_full_unstemmed Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death
title_sort use of cardiac injury markers in the postmortem diagnosis of sudden cardiac death
publisher Blackwell Publishing Inc.
publishDate 2017
url http://ir.unimas.my/id/eprint/17878/
http://onlinelibrary.wiley.com/doi/10.1111/1556-4029.13397/full
_version_ 1644512730316537856

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