A Self-Replicating Linear DNA

• Main Authors: Liew, Pei Sheng, Tan, Tze Hao, Wong, Yin Cheng, Sim, Edmund U. H., Lee, Choon-Weng, Narayanan, Kumaran
• Format: Article
• Language: English
• Published: ACS Publications 2020
• Subjects: Q Science (General)
• Online Access: http://ir.unimas.my/id/eprint/29459/1/Emund%20Ui%20Hang%20Sim.pdf; http://ir.unimas.my/id/eprint/29459/; https://pubs.acs.org/journal/asbcd6
• Institution: Universiti Malaysia Sarawak

TelN and tos are a unique DNA linearization unit isolated from bacteriophage N15. While being transferable, the TelN cleaving-rejoining activities remained stable to function on tos in both bacterial and mammalian environments. However, TelN contribution in linear plasmid replication in mammalian ce...