Matrix association region/scaffold attachment region : the crucial player in defining the positions of chromosome breaks mediated by bile acid-induced apoptosis in nasopharyngeal epithelial cells

• Main Authors: Tan, Sang-Nee, Sim, Sai-Peng
• Format: Article
• Language: English
• Published: BMC Medical Genomics 2019
• Subjects: R Medicine (General)
• Online Access: http://ir.unimas.my/id/eprint/29613/1/Matrix.pdf; http://ir.unimas.my/id/eprint/29613/; https://bmcmedgenomics.biomedcentral.com/track/pdf/10.1186/s12920-018-0465-4
• Institution: Universiti Malaysia Sarawak

It has been found that chronic rhinosinusitis (CRS) increases the risk of developing nasopharyngeal carcinoma (NPC). CRS can be caused by gastro-oesophageal reflux (GOR) that may reach nasopharynx. The major component of refluxate, bile acid (BA) has been found to be carcinogenic and genotoxic. BA...