Synthesis and Antimicrobial Studies of (E)-3-(4-Alkyloxyphenyl)-1-(2-hydroxyphenyl) prop-2-en-1-one, (E)-3-(4-Alkyloxyphenyl)-1-(4-Hydroxyphenyl)prop-2-en-1-one and their Analogues
A series of (E)-3-(4-alkyloxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (2a-c) and (E)-3-(4- alkyloxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one (3a-c) have been synthesized via Claisen-Schmidt condensation. The compounds differ in the length of alkyl groups, CnH2n+1, where n= 10, 12 and 14. The s...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IDOSI Publications
2009
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/29732/1/zainab6.pdf http://ir.unimas.my/id/eprint/29732/ https://www.idosi.org/wjc/wjc.htm |
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| Institution: | Universiti Malaysia Sarawak |
| Language: | English |
| Summary: | A series of (E)-3-(4-alkyloxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (2a-c) and (E)-3-(4-
alkyloxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one (3a-c) have been synthesized via Claisen-Schmidt
condensation. The compounds differ in the length of alkyl groups, CnH2n+1, where n= 10, 12 and 14. The
structures of the synthesized compounds were defined by elemental analysis, IR, H and C NMR. 1 13 Antimicrobial studies were carried out against E. coli ATCC 8739 to evaluate the effect of the hydroxyl and alkyl
groups of the synthesised chalcones. All the synthesized compounds have shown significant antimicrobial
activities. Chalcones (2a-c) showed better antimicrobial activities compared to chalcones (3a-c) respectively,
with (E)-3-(4-decyloxyphenyl)-1-(2-hydroxyphenyl) prop-2-en-1-one showed the highest antimicrobial activity
among the compounds tested. |
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