Synthesis, Characterization And Biological Studies Of Organotin(Iv) Complexes Of Thiosemicarbazone Ligand Derived From Pyruvic Acid: X-Ray Crystal Structure Of [Me2sn(Pat)]

• Main Authors: Zainab, Ngaini, Md. Abu, Affan, Foo, Siong Wan, Mustaffa, Shamsuddin
• Format: Article
• Language: English
• Published: UKM Publisher 2009
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://ir.unimas.my/id/eprint/30284/1/abu.pdf; http://ir.unimas.my/id/eprint/30284/; http://ejournals.ukm.my/mjas
• Institution: Universiti Malaysia Sarawak

Six organotin(IV) complexes of pyruvic acid thiosemicarbazone ligand [H2PAT, (1)] with general formula [RSnCln-1 PAT)] [R = Me2, n = 1 (2); R = Bu2, n = 1 (3); R = Ph2, n = 1 (4); R = Me, n = 2 (5); R = Bu, n = 2 (6); R = Ph, n = 2 (7)] were synthesized by direct reaction of thiosemicarbazone ligand (1), base and organotin(IV) chloride(s) in absolute methanol under N2 atmosphere. These organotin(IV) complexes were characterized by elemental analyses, molar conductivity, UV-visible, FTIR, 1 H and 13C NMR spectral studies. Among them, dimethyltin(IV) complex (2) was also characterized by X-ray crystallography diffraction analyses. The cytotoxicity of the ligand (1) as well as its organotin(IV) complexes (2-7) were determined by Artemia salina, shrimp test lethality bioassay.