Predicted Interactionsof Cyclooxygenase2 with Nasopharyngeal Cancer-linked Ribosomal Proteins, uS19 and eL27
Introduction: The Cyclooxygenase 2 (COX-2) and ribosomal proteins (RP) of uS19 and eL27 were reported to be associated with nasopharyngeal cancer (NPC). However, there is no studies on their interactions. Objective/Aim: This study aimed to extrapolated the interactions of COX-2 with uS19 and eL27 v...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Radiance Research Academy
2022
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/38472/1/Predicted%20Interactionsof.pdf http://ir.unimas.my/id/eprint/38472/ https://www.ijcrr.com/index.php |
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| Institution: | Universiti Malaysia Sarawak |
| Language: | English |
| Summary: | Introduction: The Cyclooxygenase 2 (COX-2) and ribosomal proteins (RP) of uS19 and eL27 were reported to be associated with nasopharyngeal cancer (NPC). However, there is no studies on their interactions.
Objective/Aim: This study aimed to extrapolated the interactions of COX-2 with uS19 and eL27 via in silico approach.
Methods: Bioinformatics analysis involving the web-based applications of SWISS-MODEL, ClusPro, FireDock/PatchDock and Protein Interaction Calculator (PIC), and the UniProfKB database were used for the purpose of our study.
Results: We revealed possible interactions between uS19 and eL27 with COX-2 individually. Evaluation of the interacting interface amino acid residues of the uS19-COX2 and eL27-COX2 complexes show hydrophobic and ionic bonds in the former and only hydrophobic bonds in the latter.
Conclusion: Our findings provide novel in silico evidence of COX-2’s interactions with two NPC-associated RPs (uS19 and eL27), and propose an interplay among these proteins during the oncogenesis of NPC. |
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