Unravelling the genetic history of Negritos and indigenous populations of Southeast Asia
Indigenous populations of Malaysia known as Orang Asli (OA) show huge morphological, anthropological, and linguistic diversity. However, the genetic history of these populations remained obscure. We performed a high-density array genotyping using over 2 million single nucleotide polymorphisms in thr...
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2015
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my.unimas.ir.422212023-07-12T00:59:47Z http://ir.unimas.my/id/eprint/42221/ Unravelling the genetic history of Negritos and indigenous populations of Southeast Asia Farhang, Aghakhanian Y, Yunus R, Naidu Timothy Adrian, Jinam A, Manica HB, Peng Maude E., Phipps QH426 Genetics Indigenous populations of Malaysia known as Orang Asli (OA) show huge morphological, anthropological, and linguistic diversity. However, the genetic history of these populations remained obscure. We performed a high-density array genotyping using over 2 million single nucleotide polymorphisms in three major groups of Negrito, Senoi, and Proto-Malay. Structural analyses indicated that although all OA groups are genetically closest to East Asian (EA) populations, they are substantially distinct. We identified a genetic affinity between Andamanese and Malaysian Negritos which may suggest an ancient link between these two groups. We also showed that Senoi and Proto-Malay may be admixtures between Negrito and EA populations. Formal admixture tests provided evidence of gene flow between Austro-Asiatic-speaking OAs and populations from Southeast Asia (SEA) and South China which suggest a widespread presence of these people in SEA before Austronesian expansion. Elevated linkage disequilibrium (LD) and enrichedhomozygosityfoundinOAsreflectisolationandbottlenecksexperienced.EstimatesbasedonNe andLDindicatedthatthese populationsdivergedfromEastAsiansduringthelatePleistocene(14.5to8KYA).ThecontinuumindivergencetimefromNegritosto Senoi and Proto-Malay in combination with ancestral markers provides evidences of multiple waves of migration into SEA starting with the first Out-of-Africa dispersals followed by Early Train and subsequent Austronesian expansions. Oxford University Press 2015 Article PeerReviewed text en http://ir.unimas.my/id/eprint/42221/1/Unravelling%20the.pdf Farhang, Aghakhanian and Y, Yunus and R, Naidu and Timothy Adrian, Jinam and A, Manica and HB, Peng and Maude E., Phipps (2015) Unravelling the genetic history of Negritos and indigenous populations of Southeast Asia. Genome Biology and Evolution, 7 (5). pp. 1206-1215. ISSN 1759-6653 https://academic.oup.com/gbe/article/7/5/1206/604030?login=true doi: 10.1093/gbe/evv065 |
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QH426 Genetics Farhang, Aghakhanian Y, Yunus R, Naidu Timothy Adrian, Jinam A, Manica HB, Peng Maude E., Phipps Unravelling the genetic history of Negritos and indigenous populations of Southeast Asia |
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Indigenous populations of Malaysia known as Orang Asli (OA) show huge morphological, anthropological, and linguistic diversity. However, the genetic history of these populations remained obscure. We performed a high-density array genotyping using over 2 million single nucleotide polymorphisms in three major groups of Negrito, Senoi, and Proto-Malay. Structural analyses indicated that
although all OA groups are genetically closest to East Asian (EA) populations, they are substantially distinct. We identified a genetic affinity between Andamanese and Malaysian Negritos which may suggest an ancient link between these two groups. We also showed that Senoi and Proto-Malay may be admixtures between Negrito and EA populations. Formal admixture tests provided evidence of gene flow between Austro-Asiatic-speaking OAs and populations from Southeast Asia (SEA) and South China which suggest a widespread presence of these people in SEA before Austronesian expansion. Elevated linkage disequilibrium (LD) and
enrichedhomozygosityfoundinOAsreflectisolationandbottlenecksexperienced.EstimatesbasedonNe andLDindicatedthatthese
populationsdivergedfromEastAsiansduringthelatePleistocene(14.5to8KYA).ThecontinuumindivergencetimefromNegritosto
Senoi and Proto-Malay in combination with ancestral markers provides evidences of multiple waves of migration into SEA starting with the first Out-of-Africa dispersals followed by Early Train and subsequent Austronesian expansions. |
format |
Article |
author |
Farhang, Aghakhanian Y, Yunus R, Naidu Timothy Adrian, Jinam A, Manica HB, Peng Maude E., Phipps |
author_facet |
Farhang, Aghakhanian Y, Yunus R, Naidu Timothy Adrian, Jinam A, Manica HB, Peng Maude E., Phipps |
author_sort |
Farhang, Aghakhanian |
title |
Unravelling the genetic history of Negritos and indigenous populations of Southeast Asia |
title_short |
Unravelling the genetic history of Negritos and indigenous populations of Southeast Asia |
title_full |
Unravelling the genetic history of Negritos and indigenous populations of Southeast Asia |
title_fullStr |
Unravelling the genetic history of Negritos and indigenous populations of Southeast Asia |
title_full_unstemmed |
Unravelling the genetic history of Negritos and indigenous populations of Southeast Asia |
title_sort |
unravelling the genetic history of negritos and indigenous populations of southeast asia |
publisher |
Oxford University Press |
publishDate |
2015 |
url |
http://ir.unimas.my/id/eprint/42221/1/Unravelling%20the.pdf http://ir.unimas.my/id/eprint/42221/ https://academic.oup.com/gbe/article/7/5/1206/604030?login=true |
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